Thesis
Overexpression of transcription factor specificity protein 1 (Sp1) results in centrosome amplification
Master of Science (M.S.), Drexel University
Jul 2018
DOI:
https://doi.org/10.17918/D85080
Abstract
Sp1 is overexpressed in a variety of cancers and is often associated with poor prognosis. Depletion of Sp1 results in an increase in chromosome segregation errors, which can partially be explained by Sp1 regulation of centrosome number. Dosage of centrosomal proteins is important for maintaining centrosome homeostasis in the cell. Due to the clinical relevance of Sp1 overexpression, we sought to determine the effect of Sp1 overexpression on centrosome number. Here, we report that Sp1 overexpression results in a small but significant increase in the centrosome number.
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Details
- Title
- Overexpression of transcription factor specificity protein 1 (Sp1) results in centrosome amplification
- Creators
- Parin Himanshu Mehta - DU
- Contributors
- Jane Clifford (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- ix, 31 pages
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; College of Medicine; Drexel University
- Other Identifier
- 8126; 991014632438904721