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Thesis
Pauson-Khand Cycloaddition via Boron and Silicon Tethered 1,7-Enynes
Master of Science (M.S.), Drexel University
Sep 2017
DOI:
https://doi.org/10.17918/etd-7729
Abstract
This thesis highlights the studies of silicon and boron tether synthesis of bicyclic cyclopentenones via the Pauson-Khand Reaction. The first chapter summarizes the discovery, key advancements, and mechanism of the Pauson-Khand reaction. The Pauson-Khand reaction has been utilized in total synthesis of natural products. The second chapter illustrates the Pauson-Khand reaction utilizing silicon as a tethering agent. Silicon employed as a tethering agent can lead the Pauson- Khand bicyclic cyclopentenone to a variety of synthetic applications, primarily focusing on natural product syntheses. The key developments described involves the use of catalytic cobalt to promote the Pauson-Khand reaction. The final chapter utilizes a boron tethering agent in the Pauson-Khand reaction, which has yet to be reported in literature. Boron has been utilized as a tethering agent in different reactions and shows its versatility in applications towards natural product syntheses.
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Details
- Title
- Pauson-Khand Cycloaddition via Boron and Silicon Tethered 1,7-Enynes
- Creators
- Daniel Michael Lange - DU
- Contributors
- Dionicio Martinez-Solorio (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- xiv, 116 pages
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- College of Arts and Sciences; Chemistry; Drexel University
- Other Identifier
- 7729; 991014632943104721