Thesis
Probing the structure-function relationship of the lncRNA HOTAIR
Master of Science (M.S.), Drexel University
May 2021
DOI:
https://doi.org/10.17918/00000698
Abstract
Long non-coding RNAs (lncRNAs) are a novel class of RNAs with diverse functions in both biology and disease. One such RNA is HOTAIR (HOX Transcript Antisense RNA). HOTAIR is elevated in several cancer types, including breast cancer, and has been shown to affect tumor progression and severity. However, the link between the structure and the function of HOTAIR is yet to be established. In this thesis, we begin to probe that relationship through domain deletion analysis and functional assays. We show that not all of HOTAIR is required to regulate expression of some genes, yet that all of HOTAIR is required for some facets of cell physiology.
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Details
- Title
- Probing the structure-function relationship of the lncRNA HOTAIR
- Creators
- Daniel Slusaw
- Contributors
- Srinivas Somarowthu (Advisor)
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- v, 34 pages
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; College of Medicine; Drexel University
- Other Identifier
- 991014999949304721