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Thesis
The role of DDX11 in telomere maintenance and its implications in cancer cells
Master of Science (M.S.), Drexel University
Jul 2024
DOI:
https://doi.org/10.17918/00010584
Abstract
Telomeres are enriched with G-quadruplexes (G4s), four-stranded DNA structures stabilized by the formation of bonds between guanine nucleotides. If not properly regulated, G4s can lead to detrimental effects on telomere maintenance, which is essential for cancer proliferation. Therefore, G4 ligands that block telomere maintenance are considered promising cancer therapeutics. Recent studies reported a role of DDX11 in G4 resolution. DDX11 is a DNA helicase that plays a crucial role in maintaining genomic stability by participating in DNA replication and repair. DDX11 is also overexpressed in some cancer cells, and in recent years, a possible oncogenic role of DDX11 in the onset and progression of many cancers has been emerging. This thesis aims to critically evaluate the current understanding of DDX11 and its potential relationship with telomere maintenance. Using molecular cell biology and genetic approaches, we are exploring how DDX11 deficiency affects telomeric replication and genomic integrity. We anticipate that our research will offer new insights into the pathogenesis of cancer and contribute to the development of novel therapeutic strategies for cancer treatment.
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Details
- Title
- The role of DDX11 in telomere maintenance and its implications in cancer cells
- Creators
- Sri Havya Jana
- Contributors
- Eishi Noguchi (Advisor)
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Number of pages
- x, 80 pages
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; College of Medicine; Drexel University
- Other Identifier
- 991021901914604721