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The spatiotemporal distribution of invasive pneumococcal disease (IPD) relative to vaccine coverage (PCV7) in Philadelphia: a retrospective data analysis using existing immunization & disease surveillance data
Thesis

The spatiotemporal distribution of invasive pneumococcal disease (IPD) relative to vaccine coverage (PCV7) in Philadelphia: a retrospective data analysis using existing immunization & disease surveillance data

Jessica N. Arner
Master of Public Health (M.P.H.), Drexel University
Jun 2010
DOI:
https://doi.org/10.17918/etd-3582
pdf
Arner_Jessica_20105.90 MB
PDF Access upon request, Email title, URL, or DOI to archives@drexel.edu

Abstract

Immunization and Surveillance Data Pneumococcal Disease Pennsylvania--Philadelphia Public Health Vaccines
OBJECTIVES: This project primarily aimed to identify a relationship over time and geographic distribution between the occurrences of invasive pneumococcal disease (IPD) in the entire population of the city of Philadelphia and pneumococcal conjugate vaccine (PCV7) uptake in its designated population of under five year old recipients in Philadelphia. METHODS: This project was a secondary data analysis of IPD cases recorded in the Communicable Disease Registry (CDR) and PCV7 recipients recorded in the Kids Immunization Database/Tracking System (KIDS) Registry over the time period of January 1, 2003 through December 31, 2009. IPD cases were mapped as colored dots overlaid on top of varying shaded zip code areas within the city of Philadelphia according to their PCV7 uptake rates. RESULTS: Maps show increasing rates for both first and fourth dose PCV7 uptake over the course of the study period. Correlations and simple linear regression models show PCV7 uptake rates and IPD rates are modestly positively correlated. CONCLUSIONS: The results do not appear to support the initial hypothesis. They demonstrate that, while PCV7 rates are increasing in the city of Philadelphia, so are the rates for IPD occurrence. Results may show the effects of serotype replacement. Repeating a study similar to this one after PCV13, the new vaccine that addresses the phenomenon of serotype replacement, is used regularly in vaccine schedules may be an interesting area for future research.

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