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Thesis
Therapeutic evaluation of RDP-58 and cold plasma in vivo in combination with 5 amino salicylic acid: a study in mice
Master of Science (M.S.), Drexel University
Aug 2009
DOI:
https://doi.org/10.17918/etd-3234
Abstract
Inflammatory bowel diseases (IBD) are prevalent diseases affecting the gastrointestinal system of human beings. The disease affects over 1 million people per year in the United States alone. However, the cause of the disease is still highly debated. There are two predominant diseases of IBD called Crohn's Disease and Ulcerative Colitis. The objective of the study was to evaluate the therapeutic effect of two methodologies of treatment using a novel formulation of a compound named RDP-58 and Cold Plasma (CP) technology in Dextran Sulphate Sodium (DSS) induced colitis model in mice. Cold plasma is a partly ionized gas, which is generated by a high-voltage electric field at a low pressure. CP technology has found its use in medical sterilization, wound healing, skin diseases and tissue regeneration. CP can be used with a biological interface as it has bactericidal effect, induces apoptosis, enhances coagulation and increases cell proliferation. The effect of CP as a stand-alone and in combination with 5-Amino Sa ycylic Acid (5-ASA) in the mouse colon in normal and disease conditions was evaluated. The disease activity (DAI) [Index using Body Weight, Stool Consistency, Blood in Stool as visible or occult] was measured everyday to evaluate the progress of the disease. Colon tissue was collected to estimate Tissue and DNA damage. The study brings state of the art plasma technology onto a biological platform for in vivo application in living animals. The study for the first time demonstrates in vivo application of Cold Plasma in a live animal.
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Details
- Title
- Therapeutic evaluation of RDP-58 and cold plasma in vivo in combination with 5 amino salicylic acid
- Creators
- Kalyan Chakravarthy Lnu - DU
- Contributors
- Sreekant Murthy (Advisor) - Drexel University (1970-)
- Awarding Institution
- Drexel University
- Degree Awarded
- Master of Science (M.S.)
- Publisher
- Drexel University; Philadelphia, Pennsylvania
- Resource Type
- Thesis
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems (1997-2026); Drexel University
- Other Identifier
- 3234; 991014632611204721