Journal article
α-Synuclein in Familial Alzheimer Disease: Epitope Mapping Parallels Dementia With Lewy Bodies and Parkinson Disease
Archives of neurology (Chicago), v 58(11), pp 1817-1820
01 Nov 2001
PMID: 11708989
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND α-Synuclein is a major component of Lewy bodies (LBs) in Parkinson disease and dementia with LBs and of glial cytoplasmic inclusions in multiple system atrophy. However, epitope mapping for α-synuclein is distinctive in different neurodegenerative diseases. The reasons for this are poorly understood but may reflect fundamental differences in disease mechanisms. OBJECTIVE To investigate the α-synuclein epitope mapping properties of LBs in familial Alzheimer disease. DESIGN AND SETTING We compared LBs in familial Alzheimer disease with those in synucleinopathies by probing 6 brains of persons with familial Alzheimer disease using a panel of antibodies to epitopes spanning the α-synuclein protein. Results were compared with data from brains of persons with Parkinson disease, dementia with LBs, and multiple system atrophy. RESULTS The brains of persons with familial Alzheimer disease showed consistent staining of LBs with all antibodies, similar to Parkinson disease and dementia with LBs but different from α-synuclein aggregates that occurred in multiple system atrophy. CONCLUSIONS These data suggest that the epitope profiles of α-synuclein in LBs are similar, regardless of whether the biological trigger is related to synuclein or a different genetic pathway. These findings support the hypothesis that the mechanism of α-synuclein aggregation is the same within cell types but distinctive between cell types.Arch Neurol. 2001;58:1817-1820-->
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Details
- Title
- α-Synuclein in Familial Alzheimer Disease: Epitope Mapping Parallels Dementia With Lewy Bodies and Parkinson Disease
- Creators
- Carol F Lippa - Drexel UniversityM. Luise SchmidtVirginia M.-Y LeeJohn Q Trojanowski
- Publication Details
- Archives of neurology (Chicago), v 58(11), pp 1817-1820
- Publisher
- American Medical Association
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000172055300014
- Scopus ID
- 2-s2.0-0034759869
- Other Identifier
- 991019312387104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology