Journal article
125I plaque therapy for uveal melanoma: Analysis of the impact of time and dose factors on local control
Cancer, v 77(11), pp 2356-2362
01 Jun 1996
PMID: 8635107
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Abstract
BACKGROUND
125I episcleral plaque therapy has gained wide acceptance for the treatment of uveal melanoma because of its potential to preserve vision, salvage the globe, and provide good local control. A rigorous analysis of the optimum radiation dose, dose rate, and overall treatment time has not been reported with this technique.
METHODS
One hundred fifty patients with uveal melanoma treated with 125I plaques between 1982 and 1990 and included in the uveal melanoma study (UMS) database of the Wills Eye Hospital were analyzed. Mean patient age was 60.7 years (range: 17.7–84.6 years). Initial mean tumor size was 9.7 × 8.5 × 3.7 mm with a range of 4.5 to 21.5 mm in basal dimension and 1.2 to 11.8 mm in height. Mean dose to the tumor apex was 94.77 gray (Gy) (29.5–141 Gy). Mean dose rate to the tumor apex was 92.9 cGy/hr (10–292 cGy/hr); the mean dose to the base was 359 Gy (181–692 Gy); the mean dose rate to the base was 348 cGy/hr (112–893 cGy/hr); and mean duration of treatment was 124.7 hours (range: 28–333 hours).
RESULTS
With a median follow‐up of 68 months, there have been 33 local failures. Mean time to local failure was 19 months (range: 6–78 months). Actuarial local control is 81% at 5 years. Multivariate analysis demonstrates significant correlation of local failure with larger tumor dimension (P = 0.0046), close proximity to the optic disc (P = 0.0029), lower radiation dose to the tumor apex (P = 0.03), lower radiation dose rate to the tumor apex and base (P = 0.01 and 0.03), and longer overall treatment time (P = <0.0001).
CONCLUSIONS
This retrospective analysis reinforces the importance of dose rate, minimum tumor dose, overall treatment time, maximum tumor basal dimension, and proximity to the optic nerve in the treatment of uveal melanoma. Cancer 1996;77:2356‐62.
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Details
- Title
- 125I plaque therapy for uveal melanoma: Analysis of the impact of time and dose factors on local control
- Creators
- Jeanne M. Quivey - Department of Radiation Oncology University of California San Francisco San Francisco, CaliforniaJames Augsburger - Wills Eye HospitalLesley Snelling - Hahnemann University HospitalLuther W. Brady - Hahnemann University Hospital
- Publication Details
- Cancer, v 77(11), pp 2356-2362
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:A1996UM08900026
- Scopus ID
- 2-s2.0-0029664644
- Other Identifier
- 991019169620204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology