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Journal article
14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis
Frontiers in molecular neuroscience, v 10, pp 318-318
12 Oct 2017
PMID: 29075177
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The 14-3-3 proteins are a family of highly conserved, multifunctional proteins that are highly expressed in the brain during development. Cumulatively, the seven 14-3-3 isoforms make up approximately 1% of total soluble brain protein. Over the last decade, evidence has accumulated implicating the importance of the 14-3-3 protein family in the development of the nervous system, in particular cortical development, and have more recently been recognized as key regulators in a number of neurodevelopmental processes. In this review we will discuss the known roles of each 14-3-3 isoform in the development of the cortex, their relation to human neurodevelopmental disorders, as well as the challenges and questions that are left to be answered. In particular, we focus on the 14-3-3 isoforms and their involvement in the three key stages of cortical development; neurogenesis and differentiation, neuronal migration and neuromorphogenesis and synaptogenesis.
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Details
- Title
- 14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis
- Creators
- Brett Cornell - Drexel UniversityKazuhito Toyo-oka - Drexel University
- Publication Details
- Frontiers in molecular neuroscience, v 10, pp 318-318
- Publisher
- Frontiers Media S.A
- Grant note
- NS096098 / National Institute of Neurological Disorders and Stroke
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000412741200001
- Scopus ID
- 2-s2.0-85032289219
- Other Identifier
- 991019168981104721
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- Web of Science research areas
- Neurosciences