Journal article
14-3-3 epsilon and zeta Regulate Neurogenesis and Differentiation of Neuronal Progenitor Cells in the Developing Brain
The Journal of neuroscience, v 34(36), pp 12168-12181
03 Sep 2014
PMID: 25186760
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
During brain development, neural progenitor cells proliferate and differentiate into neural precursors. These neural precursors migrate along the radial glial processes and localize at their final destination in the cortex. Numerous reports have revealed that 14-3-3 proteins are involved in many neuronal activities, although their functions in neurogenesis remain unclear. Here, using 14-3-3 epsilon/zeta double knock-out mice, we found that 14-3-3 proteins are important for proliferation and differentiation of neural progenitor cells in the cortex, resulting in neuronal migration defects and seizures. 14-3-3 deficiency resulted in the increase of delta-catenin and the decrease of beta-catenin and alpha N-catenin. 14-3-3 proteins regulated neuronal differentiation into neurons via direct interactions with phosphorylated delta-catenin to promote F-actin formation through a catenin/Rho GTPase/Limk1/cofilin signaling pathway. Conversely, neuronal migration defects seen in the double knock-out mice were restored by phosphomimic Ndel1 mutants, but not delta-catenin. Our findings provide new evidence that 14-3-3 proteins play important roles in neurogenesis and neuronal migration via the regulation of distinct signaling cascades.
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Details
- Title
- 14-3-3 epsilon and zeta Regulate Neurogenesis and Differentiation of Neuronal Progenitor Cells in the Developing Brain
- Creators
- Kazuhito Toyo-oka - University of California, San FranciscoTomoka Wachi - University of California, San FranciscoRobert F. Hunt - Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143Scott C. Baraban - Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143Shinichiro Taya - Nagoya UniversityHayley Ramshaw - Centre for Cancer BiologyKozo Kaibuchi - Nagoya UniversityQuenten P. Schwarz - Centre for Cancer BiologyAngel F. Lopez - Centre for Cancer BiologyAnthony Wynshaw-Boris - University of California, San Francisco
- Publication Details
- The Journal of neuroscience, v 34(36), pp 12168-12181
- Publisher
- Soc Neuroscience
- Number of pages
- 14
- Grant note
- R01HD047380 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) NS041310; HD047380; NS073159; NS040272; NS085046 / National Alliance for Research on Schizophrenia and Depression Young Investigator Award, National Institutes of Health National Institute of Health fellowship R01NS041310 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000341765400027
- Scopus ID
- 2-s2.0-84906920614
- Other Identifier
- 991019168587604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences