Journal article
2013 Benjamin Franklin Medal in Life Science presented to Rudolf Jaenisch
Journal of the Franklin Institute, v 352(7), pp 2587-2590
Jul 2015
Abstract
The discovery of the genetic code established that the sequence of base-pairs within DNA contains the instructions for regenerating the organism from which the DNA came, and is transmitted from generation to generation. It therefore came as a surprise that there were also heritable controls for gene expression that were independent of the DNA sequence information. This is known as epigenetics, and is mainly controlled by methylation of DNA. Rudolf Jaenisch played a pivotal role in establishing the nature of such epigenetic control, and showing that it is also featured in cancers as well as normal development. Moreover, he has shown how these epigenetic mechanisms may be controlled to allow cells to be cloned, giving the hope of someday being able to regenerate damaged or diseased organs.
Metrics
13 Record Views
Details
- Title
- 2013 Benjamin Franklin Medal in Life Science presented to Rudolf Jaenisch
- Creators
- Frank A. Ferrone - Drexel University
- Publication Details
- Journal of the Franklin Institute, v 352(7), pp 2587-2590
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000358699500011
- Scopus ID
- 2-s2.0-84937975361
- Other Identifier
- 991019168899704721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Automation & Control Systems
- Engineering, Electrical & Electronic
- Engineering, Multidisciplinary
- Mathematics, Interdisciplinary Applications