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Journal article
2D Materials and Primary Human Dendritic Cells: A Comparative Cytotoxicity Study
Small (Weinheim an der Bergstrasse, Germany), v 18(20), 2107652
01 May 2022
PMID: 35451183
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human health can be affected by materials indirectly through exposure to the environment or directly through close contact and uptake. With the ever-growing use of 2D materials in many applications such as electronics, medical therapeutics, molecular sensing, and energy storage, it has become more pertinent to investigate their impact on the immune system. Dendritic cells (DCs) are highly important, considering their role as the main link between the innate and the adaptive immune system. By using primary human DCs, it is shown that hexagonal boron nitride (hBN), graphene oxide (GO) and molybdenum disulphide have minimal effects on viability. In particular, it is evidenced that hBN and GO increase DC maturation, while GO leads to the release of reactive oxygen species and pro-inflammatory cytokines. hBN and MoS
increase T cell proliferation with and without the presence of DCs. hBN in particular does not show any sign of downstream T cell polarization. The study allows ranking of the three materials in terms of inherent toxicity, providing the following trend: GO > hBN ≈ MoS
, with GO the most cytotoxic.
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Details
- Title
- 2D Materials and Primary Human Dendritic Cells: A Comparative Cytotoxicity Study
- Creators
- Hazel Lin - CNRS, Immunology, Immunopathology and Therapeutic Chemistry UPR 3572, University of Strasbourg, ISIS, Strasbourg, 67000, FranceShiyuan Peng - Institut de Biologie Moléculaire et CellulaireShi Guo - Institut de Biologie Moléculaire et CellulaireBaojin Ma - Institut de Biologie Moléculaire et CellulaireMatteo Andrea Lucherelli - Institut de Biologie Moléculaire et CellulaireCathy Royer - Centre de Neurophysique Physiologie et PathologieStefano Ippolito - Institut de Science et d'Ingénierie SupramoléculairesPaolo Samorì - Université de StrasbourgAlberto Bianco - Institut de Biologie Moléculaire et Cellulaire
- Publication Details
- Small (Weinheim an der Bergstrasse, Germany), v 18(20), 2107652
- Publisher
- Wiley
- Grant note
- 881603 / EU Graphene Flagship project ANR-10-LABX-0026_CSC / LabEx project Chemistry of Complex Systems ANR-11-EQPX-022 / Investissements d'Avenir
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Nanomaterials Institute
- Web of Science ID
- WOS:000789498300001
- Scopus ID
- 2-s2.0-85128550654
- Other Identifier
- 991021931766904721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied
- Physics, Condensed Matter