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2H double quantum filtered (DQF) NMR spectroscopy of the nucleus pulposus tissues of the intervertebral disc
Journal article   Open access   Peer reviewed

2H double quantum filtered (DQF) NMR spectroscopy of the nucleus pulposus tissues of the intervertebral disc

William Perea, Marco Cannella, Jun Yang, Alexander J Vega, Tatyana Polenova and Michele Marcolongo
Magnetic resonance in medicine, v 57(6), pp 990-999
Jun 2007
DOI: https://doi.org/10.1002/mrm.21231
PMID: 17534920
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1002/mrm.21231View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

deuterium DQF NMR spectroscopy double quantum filtering intervertebral disc water dynamics nucleus pulposus
Deuterium (2H) double‐quantum filtered (DQF) NMR spectroscopy of nucleus pulposus (NP) tissues from human intervertebral discs is reported. The DQF spectral intensities, DQ build‐up rates, and DQF‐detected rotating‐frame spin‐lattice relaxation times are sensitive to the degree of hydration of the NP tissue, and display a monotonous correlation with age between 15 and 80 years. The implications of this work are that the changes in water dynamics as detected via DQF NMR spectroscopy may be used as a probe of tissue degeneration in NP, particularly in the early stages of degeneration to which most standard NMR methods are not sensitive. Magn Reson Med 57:990–999, 2007. © 2007 Wiley‐Liss, Inc.

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Collaboration types
Domestic collaboration
Web of Science research areas
Radiology, Nuclear Medicine & Medical Imaging
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