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Journal article
3D Harmonic and Subharmonic Imaging for Characterizing Breast Lesions A Multi-Center Clinical Trial
JOURNAL OF ULTRASOUND IN MEDICINE, v 41(7), pp 1667-1675
Jul 2022
PMID: 34694019
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective Breast cancer is the most frequent type of cancer among women. This multi-center study assessed the ability of 3D contrast-enhanced ultrasound to characterize suspicious breast lesions using clinical assessments and quantitative parameters. Methods Women with suspicious breast lesions scheduled for biopsy were enrolled in this prospective, study. Following 2D grayscale ultrasound and power Doppler imaging (PDI), a contrast agent (Definity; Lantheus) was administrated. Contrast-enhanced 3D harmonic imaging (HI; transmitting/receiving at 5.0/10.0 MHz), as well as 3D subharmonic imaging (SHI; transmitting/receiving at 5.8/2.9 MHz), were performed using a modified Logiq 9 scanner (GE Healthcare). Five radiologists independently scored the imaging modes (including standard-of-care imaging) using a 7-point BIRADS scale as well as lesion vascularity and diagnostic confidence. Parametric volumes were constructed from time-intensity curves for vascular heterogeneity, perfusion, and area under the curve. Diagnostic accuracy was determined relative to pathology using receiver operating characteristic (ROC) and reverse, step-wise logistical regression analyses. The kappa-statistic was calculated for inter-reader agreement. Results Data were successfully acquired in 219 cases and biopsies indicated 164 (75%) benign and 55 (25%) malignant lesions. SHI depicted more anastomoses and vascularity than HI (P < .021), but there were no differences by pathology (P > .27). Ultrasound achieved accuracies of 82 to 85%, which was significantly better than standard-of-care imaging (72%; P < .03). SHI increased diagnostic confidence by 3 to 6% (P < .05), but inter-reader agreements were medium to low (kappa < 0.52). The best regression model achieved 97% accuracy by combining clinical reads and parametric SHI. Conclusions Combining quantitative 3D SHI parameters and clinical assessments improves the characterization of suspicious breast lesions.
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Details
- Title
- 3D Harmonic and Subharmonic Imaging for Characterizing Breast Lesions A Multi-Center Clinical Trial
- Publication Details
- JOURNAL OF ULTRASOUND IN MEDICINE, v 41(7), pp 1667-1675
- Publisher
- WILEY; HOBOKEN
- Number of pages
- 8
- Grant note
- We gratefully acknowledge the efforts of the many research coordinators who helped recruit subjects for this trial. This work was supported by National Institutes of Health Grant R01 CA140338, U.S. Army Medical Research Material Command Grant W81XWH-11-1-0630, and by Lantheus Medical Imaging, N. Billerica, MA, which supplied the ultrasound contrast agent Definity.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000710472600001
- Scopus ID
- 2-s2.0-85117843661
- Other Identifier
- 991021860753504721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging