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Journal article
3D Printed Conductive Multiscale Nerve Guidance Conduit with Hierarchical Fibers for Peripheral Nerve Regeneration
Advanced science, v 10(12), 2205744
01 Apr 2023
PMID: 36808712
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nerve guidance conduits (NGCs) have become a promising alternative for peripheral nerve regeneration; however, the outcome of nerve regeneration and functional recovery is greatly affected by the physical, chemical, and electrical properties of NGCs. In this study, a conductive multiscale filled NGC (MF-NGC) consisting of electrospun poly(lactide-co-caprolactone) (PCL)/collagen nanofibers as the sheath, reduced graphene oxide /PCL microfibers as the backbone, and PCL microfibers as the internal structure for peripheral nerve regeneration is developed. The printed MF-NGCs presented good permeability, mechanical stability, and electrical conductivity, which further promoted the elongation and growth of Schwann cells and neurite outgrowth of PC12 neuronal cells. Animal studies using a rat sciatic nerve injury model reveal that the MF-NGCs promote neovascularization and M2 transition through the rapid recruitment of vascular cells and macrophages. Histological and functional assessments of the regenerated nerves confirm that the conductive MF-NGCs significantly enhance peripheral nerve regeneration, as indicated by improved axon myelination, muscle weight increase, and sciatic nerve function index. This study demonstrates the feasibility of using 3D-printed conductive MF-NGCs with hierarchically oriented fibers as functional conduits that can significantly enhance peripheral nerve regeneration.
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Details
- Title
- 3D Printed Conductive Multiscale Nerve Guidance Conduit with Hierarchical Fibers for Peripheral Nerve Regeneration
- Creators
- Yongcong Fang - "Biomanufacturing and Engineering Living Systems" Innovation International Talents Base (111 Base), Beijing, 100084, P. R. ChinaChengjin Wang - "Biomanufacturing and Engineering Living Systems" Innovation International Talents Base (111 Base), Beijing, 100084, P. R. ChinaZibo Liu - Tsinghua UniversityJeonghoon Ko - Living SystemsLi Chen - Tsinghua UniversityTing Zhang - Tsinghua UniversityZhuo Xiong - "Biomanufacturing and Engineering Living Systems" Innovation International Talents Base (111 Base), Beijing, 100084, P. R. ChinaLei Zhang - Tsinghua UniversityWei Sun - Drexel University, Mechanical Engineering and Mechanics
- Publication Details
- Advanced science, v 10(12), 2205744
- Publisher
- Wiley
- Grant note
- 20197050024 / Tsinghua University Initiative Scientific Research Program 2018YFA0703004 / National Key Research and Development Program of China 2021TQ0184 / China Postdoctoral Science Foundation 53330200321 / New Faculty Start-up Funding of Tsinghua University U21A20394 / National Natural Science Foundation of China
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000934673900001
- Scopus ID
- 2-s2.0-85148449794
- Other Identifier
- 991021861185304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology