Journal article
3D Printing of Shear-Thinning Hyaluronic Acid Hydrogels with Secondary Cross-Linking
ACS biomaterials science & engineering, v 2(10), pp 1743-1751
01 Oct 2016
PMID: 33440472
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The development of printable biomaterial inks is critical to the application of 3D printing in biomedicine. To print high-resolution structures with fidelity to a computer aided design, materials used in 3D printing must be capable of being deposited on a surface and maintaining a printed structure. A dual-cross-linking hyaluronic acid system was studied here as a printable hydrogel ink, which encompassed both shear-thinning and self-healing behaviors via guest host bonding, as well as covalent cross-linking for stabilization using photopolymerization. When either guest host assembly or covalent cross-linking was used alone, long-term stable structures were not formed, because of network relaxation after printing or dispersion of the ink filaments prior to stabilization, respectively. The dual-cross-linking hydrogel filaments formed structures with greater than 16 layers that were stable over a month with no loss in mechanical properties and the printed filament size ranged from 100 to 500 mu m, depending on printing parameters (needle size, speed, and extrusion flux). Printed structures were further functionalized (i.e., RGD peptide) to support cell adhesion. This work highlights the importance of ink formulation and cross-linking on the printing of stable hydrogel structures.
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Details
- Title
- 3D Printing of Shear-Thinning Hyaluronic Acid Hydrogels with Secondary Cross-Linking
- Creators
- Liliang Ouyang - University of PennsylvaniaChristopher B. Highley - University of PennsylvaniaChristopher B. Rodell - University of PennsylvaniaWei Sun - Tsinghua UniversityJason A. Burdick - University of Pennsylvania
- Publication Details
- ACS biomaterials science & engineering, v 2(10), pp 1743-1751
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 9
- Grant note
- American Heart Association National Science Foundation MRSEC grant at the University of Pennsylvania 201506210148 / China Scholarship Council
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000385213700008
- Scopus ID
- 2-s2.0-84990973243
- Other Identifier
- 991019168205004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Materials Science, Biomaterials