Journal article
3D network model of NO transport in tissue
Medical & biological engineering & computing, Vol.49(6), pp.633-647
Jun 2011
PMID: 21431938
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We developed a mathematical model to simulate shear stress-dependent nitric oxide (NO) production and transport in a 3D microcirculatory network based on published data. The model consists of a 100 μm × 500 μm × 75 μm rectangular volume of tissue containing two arteriole-branching trees, and nine capillaries surrounding the vessels. Computed distributions for NO in blood, vascular walls, and surrounding tissue were affected by hematocrit (Hct) and wall shear stress (WSS) in the network. The model demonstrates that variations in the red blood cell (RBC) distribution and WSS in a branching network can have differential effects on computed NO concentrations due to NO consumption by RBCs and WSS-dependent changes in NO production. The model predicts heterogeneous distributions of WSS in the network. Vessel branches with unequal blood flow rates gave rise to a range of WSS values and therefore NO production rates. Despite increased NO production in a branch with higher blood flow and WSS, vascular wall NO was predicted to be lower due to greater NO consumption in blood, since the microvascular Hct increased with redistribution of RBCs at the vessel bifurcation. Within other regions, low WSS was combined with decreased NO consumption to enhance the NO concentration.
Metrics
6 Record Views
Details
- Title
- 3D network model of NO transport in tissue
- Creators
- Xuewen Chen - Department of Plant Biology Michigan State University East Lansing MI 48910 USADonald Buerk - School of Biomedical Engineering, Science, and Health Systems Drexel University Philadelphia PA 19104 USAKenneth Barbee - School of Biomedical Engineering, Science, and Health Systems Drexel University Philadelphia PA 19104 USAPatrick Kirby - School of Biomedical Engineering, Science, and Health Systems Drexel University Philadelphia PA 19104 USADov Jaron - School of Biomedical Engineering, Science, and Health Systems Drexel University Philadelphia PA 19104 USA
- Publication Details
- Medical & biological engineering & computing, Vol.49(6), pp.633-647
- Publisher
- Springer-Verlag; Berlin/Heidelberg
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Identifiers
- 991014878066504721
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Web of Science research areas
- Computer Science, Interdisciplinary Applications
- Engineering, Biomedical
- Mathematical & Computational Biology
- Medical Informatics