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A 12-year-old African American girl with subacute bilateral ophthalmoplegia
Journal article   Peer reviewed

A 12-year-old African American girl with subacute bilateral ophthalmoplegia

Amir Bar, Jacqueline Urbine, Yasmine Bahora, Meghan Berkenstock, Jennifer Vodzak, Hamalatha Guruprasad, Manisha Sinha, Thair Abed and Agustín Legido
Seminars in pediatric neurology, v 21(2)
Jun 2014
DOI: https://doi.org/10.1016/j.spen.2014.04.028
PMID: 25149958
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

African Americans Brain - diagnostic imaging Brain - pathology Child Diagnosis, Differential Encephalomyelitis, Acute Disseminated - diagnosis Encephalomyelitis, Acute Disseminated - drug therapy Encephalomyelitis, Acute Disseminated - pathology Encephalomyelitis, Acute Disseminated - physiopathology Female Humans Magnetic Resonance Imaging Ophthalmoplegia - diagnosis Ophthalmoplegia - drug therapy Ophthalmoplegia - pathology Ophthalmoplegia - physiopathology Tomography, X-Ray Computed
A twelve-year-old African-American female presented with two week history of progressively worsening headache and fatigue, and vision difficulties for the past week. The physical examination was normal. The neurological evaluation was normal, except for cranial nerves (CN) testing, which showed bilateral restriction of adduction (CN III) and up gaze (CN IV) motions, vertical nystagmus, and left side facial paresis of central origin (CN VII). The bilateral exotropia and ophthalmoplegia are characteristics of WEBINO (Wall-Eyed Bilateral Intranuclear Ophthalmoplegia) syndrome, associated to a brain stem structural lesion. The following causes were evaluated and ruled out: tumor, infection, ischemic stroke, non-infectious inflammation. Pediatric Acquired Demyelinating Syndromes were then considered. Neuromyelitis Optica was ruled out in the absence of neuritis and normal spinal cord MRI. The differential diagnosis between Clinically Isolated Syndrome and Acute Demyelinating Encephalomyelitis, causing an isolated brain stem syndrome, is discussed.

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Collaboration types
Domestic collaboration
Web of Science research areas
Clinical Neurology
Pediatrics
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