Journal article
A 50th Order Reaction Predicted and Observed for Sickle Hemoglobin Nucleation
Journal of molecular biology, Vol.256(2)
1996
PMID: 8594190
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sickle hemoglobin polymerization exhibits a striking sensitivity to initial concentration, with characteristic reaction times that exhibit |similar|30th power dependence on the concentration. This extraordinary reaction order is encompassed by a novel double nucleation mechanism that predicts |similar|50th power dependence of the homogeneous nucleation rate. Using a technique that allows individual homogeneous nucleation events to be monitored, we have measured a concentration dependence of 47±5, in excellent agreement with the predictions of the model. Absolute nucleation rates agree with predictions as well.
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Details
- Title
- A 50th Order Reaction Predicted and Observed for Sickle Hemoglobin Nucleation
- Creators
- Zhiqi CaoFrank A Ferrone
- Publication Details
- Journal of molecular biology, Vol.256(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Identifiers
- 991014878087404721
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- Biochemistry & Molecular Biology