Journal article
A 50th Order Reaction Predicted and Observed for Sickle Hemoglobin Nucleation
Journal of molecular biology, v 256(2)
1996
PMID: 8594190
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sickle hemoglobin polymerization exhibits a striking sensitivity to initial concentration, with characteristic reaction times that exhibit |similar|30th power dependence on the concentration. This extraordinary reaction order is encompassed by a novel double nucleation mechanism that predicts |similar|50th power dependence of the homogeneous nucleation rate. Using a technique that allows individual homogeneous nucleation events to be monitored, we have measured a concentration dependence of 47±5, in excellent agreement with the predictions of the model. Absolute nucleation rates agree with predictions as well.
Metrics
Details
- Title
- A 50th Order Reaction Predicted and Observed for Sickle Hemoglobin Nucleation
- Creators
- Zhiqi CaoFrank A Ferrone
- Publication Details
- Journal of molecular biology, v 256(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:A1996TW56500002
- Scopus ID
- 2-s2.0-0029995324
- Other Identifier
- 991014878087404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology