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A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination367.36 kB
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Journal article
A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination
Environmental health perspectives, v 124(6), pp 813-821
01 Jun 2016
PMID: 26649893
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Reasons for the highly variable and often poor protection conferred by the Mycobacterium bovis bacille Calmette-Guerin (BCG) vaccine are multifaceted and poorly understood.
OBJECTIVES: We aimed to determine whether early-life exposure to PCBs (polychlorinated biphenyls) and DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene] reduces 6-month infant BCG vaccine response.
METHODS: Data came from families participating in a prospective birth cohort in eastern Slovakia. At birth, maternal and cord blood were collected for chemical analyses, and infants were immunized with BCG. Blood was collected from infants for chemical analyses and to determine 6-month BCG-specific immunoglobulin (Ig) G and IgA levels. Multivariable linear regression models were fit to examine chemical-BCG associations among approximately 500 mother-infant pairs, with adjustment for confounders.
RESULTS: The median 6-month infant concentration of the prevalent congener PCB-153 was 113 ng/g lipid [interquartile range (IQR): 37-248], and 388 ng/g lipid (IQR: 115-847) for DDE. Higher 6-month infant concentrations of PCB-153 and DDE were strongly associated with lower 6-month BCG-specific antibody levels. For instance, BCG-specific IgG levels were 37% lower for infants with PCB-153 concentrations at the 75th percentile compared to the 25th percentile (95% CI: -42, -32; p < 0.001). Results were similar in magnitude and precision for DDE. There was also evidence of PCB-DDE additivity, where exposure to both compounds reduced anti-BCG levels more than exposure to either compound alone.
CONCLUSIONS: The associations observed in this study indicate that environmental exposures may be overlooked contributors to poorer responses to BCG vaccine. The overall association between these exposures and tuberculosis incidence is unknown.
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Details
- Title
- A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination
- Creators
- Todd A. Jusko - University of RochesterAnneclaire J. De Roos - Drexel UniversitySue Y. Lee - University of RochesterKelly Thevenet-Morrison - University of RochesterStephen M. Schwartz - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaMarc-Andre Verner - University of MontrealLubica Palkovicova Murinova - Slovak Medical UniversityBeata Drobna - Slovak Medical UniversityAnton Kocan - Masaryk UniversityAnna Fabisikova - University of ViennaKamil Conka - Slovak Medical UniversityTomas Trnovec - Slovak Medical UniversityIrva Hertz-Picciotto - University of California, DavisB. Paige Lawrence - University of Rochester
- Publication Details
- Environmental health perspectives, v 124(6), pp 813-821
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 9
- Grant note
- R01 CA096525; K12 ES019852; R01 ES017250; P30 ES001247; P30 ES007033; T32 ES007262; T32 RR023256 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32RR023256 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R01CA096525 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Universite' de Montreal Public Health Research Institute (IRSPUM) P30ES007033 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000377081300025
- Scopus ID
- 2-s2.0-84971517013
- Other Identifier
- 991019169631904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology