Journal article
A Broad-Spectrum Microbicide with Virucidal Activity against Sexually Transmitted Viruses
Antimicrobial agents and chemotherapy, v 43(2), pp 314-321
Feb 1999
PMID: 9925525
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sodium dodecyl sulfate (SDS), an alkyl sulfate surfactant derived from an organic alcohol, possesses surfactant properties but also denatures and unfolds both monomeric and subunit proteins. In preliminary experiments, we demonstrated that SDS is a potent inactivator of herpes simplex virus type 2 and human immunodeficiency virus type 1 at concentrations comparable to those used for the surfactant nonoxynol-9. We hypothesized that SDS might be capable of denaturing the capsid proteins of nonenveloped viruses. In this report, we demonstrate inactivation of rabbit, bovine, and human papillomaviruses after brief treatment with dilute solutions of SDS. Effective concentrations were nontoxic to rabbit skin and to split-thickness grafts of human foreskin epithelium. This is the first report of a microbicidal surfactant that will inactivate papillomaviruses. We propose that SDS is now a candidate microbicide for formulation and testing with humans.
Metrics
Details
- Title
- A Broad-Spectrum Microbicide with Virucidal Activity against Sexually Transmitted Viruses
- Creators
- M. K Howett - Department of Microbiology and ImmunologyE. B Neely - Department of Microbiology and ImmunologyN. D Christensen - Department of Microbiology and ImmunologyB Wigdahl - Department of Microbiology and ImmunologyF. C Krebs - Department of Microbiology and ImmunologyD Malamud - Department of Microbiology and ImmunologyS. D Patrick - Department of Microbiology and ImmunologyM. D Pickel - Department of Microbiology and ImmunologyP. A Welsh - Department of Microbiology and ImmunologyC. A Reed - Department of Microbiology and ImmunologyM. G Ward - Department of Microbiology and ImmunologyL. R Budgeon - Department of Microbiology and ImmunologyJ. W Kreider - Department of Microbiology and Immunology
- Publication Details
- Antimicrobial agents and chemotherapy, v 43(2), pp 314-321
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000078424200019
- Scopus ID
- 2-s2.0-0033034661
- Other Identifier
- 991014877706604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Microbiology
- Pharmacology & Pharmacy