Journal article
A Case-Control Study of Occupational Exposure to Trichloroethylene and Non-Hodgkin Lymphoma
Environmental health perspectives, v 119(2), pp 232-238
01 Feb 2011
PMCID: PMC3040611
PMID: 21370516
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Previous epidemiologic findings suggest an association between exposure to trichloro-ethylene (TCE), a chlorinated solvent primarily used for vapor degreasing of metal parts, and non-Hodgkin lymphoma (NHL).
OBJECTIVES: We investigated the association between occupational TCE exposure and NHL within a population-based case-control study using detailed exposure assessment methods.
METHODS: Cases (n = 1,189; 76% participation rate) and controls (n = 982; 52% participation rate) provided information on their occupational histories and, for selected occupations, on possible workplace exposure to TCE using job-specific interview modules. An industrial hygienist assessed potential TCE exposure based on this information and a review of the TCE industrial hygiene literature. We computed odds ratios (ORs) and 95% confidence intervals (CIs) relating NHL and different metrics of estimated TCE exposure, categorized using tertiles among exposed controls, with unexposed subjects as the reference group.
RESULTS: We observed associations with NHL for the highest tertiles of estimated average weekly exposure (23 exposed cases; OR = 2.5; 95% CI, 1.1-6.1) and cumulative exposure (24 exposed cases; OR = 2.3; 95% CI, 1.0-5.0) to TCE. Tests for trend with these metrics surpassed or approached statistical significance (p-value for trend = 0.02 and 0.08, respectively); however, we did not observe dose-response relationships across the exposure levels. Overall, neither duration nor intensity of exposure was associated with NHL, although we observed an association with the lowest tertile of exposure duration (OR = 2.1; 95% CI, 1.0-4.7).
CONCLUSIONS: Our findings offer additional support for an association between high levels of exposure to TCE and increased risk of NHL. However, we cannot rule out the possibility of confounding from other chlorinated solvents used for vapor degreasing and note that our exposure assessment methods have not been validated.
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Details
- Title
- A Case-Control Study of Occupational Exposure to Trichloroethylene and Non-Hodgkin Lymphoma
- Creators
- Mark P. Purdue - National Institutes of HealthBerit Bakke - National Institutes of HealthPatricia Stewart - Product Innovation and Engineering (United States, Saint James) - LLCAnneclaire J. De Roos - University of WashingtonMaryjean Schenk - Wayne State UniversityCharles F. Lynch - University of IowaLeslie Bernstein - City Of Hope National Medical CenterLindsay M. Morton - National Institutes of HealthJames R. Cerhan - College Station Medical CenterRichard K. Severson - Wayne State UniversityWendy Cozen - University of Southern CaliforniaScott Davis - University of WashingtonNathaniel Rothman - National Institutes of HealthPatricia Hartge - National Institutes of HealthJoanne S. Colt - National Institutes of Health
- Publication Details
- Environmental health perspectives, v 119(2), pp 232-238
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 7
- Grant note
- N01PC067010 / DIVISION OF CANCER CONTROL &POPULATION SCIENCE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); NIH National Cancer Institute- Division of Cancer Control & Population Sciences ZIACP010170 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) NIH, National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) N01-PC-65064; N01-PC-67008; N01-PC-67009; N01-PC-67010; N02-PC-71105 / Public Health Service; United States Department of Health & Human Services; United States Public Health Service
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000286803400026
- Scopus ID
- 2-s2.0-79955850160
- Other Identifier
- 991020099925904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology