Journal article
A Case Study of Brain Morphometry in Triplets Discordant for Down Syndrome
American journal of medical genetics. Part A, v 167(5), pp 1107-1110
01 May 2015
PMID: 25820455
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Down syndrome, the most common genetic cause of intellectual disability, offers the opportunity to explore the associations between genetics and both neuroanatomic and neuropsychological phenotypes. This case report summarizes the findings of a neuroimaging and neuropsychology study of two adolescent females with Down syndrome and their same-sex discordant triplet siblings (one from each family; n=4). Using high-resolution magnetic resonance imaging and surface based morphometric approaches, we offer the first in vivo report of cortical surface area reductions and increases in the thickness of the cortical sheet in youth with Down syndrome relative to their typically developing same-sex triplet siblings. (c) 2015 Wiley Periodicals, Inc.
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Details
- Title
- A Case Study of Brain Morphometry in Triplets Discordant for Down Syndrome
- Creators
- Elizabeth I. Adeyemi - National Institute of Mental HealthJay N. Giedd - University of California, San DiegoNancy Raitano Lee - Drexel University
- Publication Details
- American journal of medical genetics. Part A, v 167(5), pp 1107-1110
- Publisher
- Wiley
- Number of pages
- 4
- Grant note
- ZIAMH002794 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) NCT00001246; 89-M-0006 / National Institutes of Health, National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000353171900019
- Scopus ID
- 2-s2.0-84927722638
- Other Identifier
- 991019168114804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity