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Journal article
A Case of Double Expresser Diffuse Large B Cell Lymphoma Treated with R-CODOX-M/R-IVAC
Case reports in oncology, v 12(2), pp 595-602
01 May 2019
PMID: 31543774
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Diffuse Large B Cell Lymphoma (DLBCL) is a heterogeneous disease with a variety of chromosomal abnormalities contributing to differences in management. While it is known that Double Hit Lymphomas (DHL) warrant more aggressive chemotherapy regimens, debate remains on how to treat Double Expresser Lymphomas (DEL). We present a case of a DEL treated with an aggressive regimen of 2 alternating cycles of R-CODOX-M (rituximab, cyclophosphamide, doxorubicin, vincristine and methotrexate) and R-IVAC (rituximab, ifosfamide, etoposide and high dose cytarabine). The regimen resulted in a significant response to treatment with marked reduction in tumor size and avidity, and an acceptable side effect profile. There was, however, residual metabolic activity on repeat PET CT scan. After consolidation with 36 Grey radiotherapy, a PET CT demonstrated a complete metabolic response. Debate remains regarding treatment approaches in DEL. Our case supports the categorization of DEL alongside DHL as resistant lymphomas requiring a more aggressive regimen than standard therapy.
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Details
- Title
- A Case of Double Expresser Diffuse Large B Cell Lymphoma Treated with R-CODOX-M/R-IVAC
- Creators
- Thomas Bemis - Drexel UniversityJonathan Ioanitescu - Drexel UniversityLynn Mackovick - Drexel University College of Medicine, Department of Internal Medicine, Philadelphia, Pennsylvania, USA Drexel University College of Medicine, Department of Pathology, Philadelphia, Pennsylvania, USAAzzam Hammad - Drexel UniversityJascha Rubin - Drexel University College of Medicine, Department of Internal Medicine, Philadelphia, Pennsylvania, USA Drexel University College of Medicine, Department of Pathology, Philadelphia, Pennsylvania, USA
- Publication Details
- Case reports in oncology, v 12(2), pp 595-602
- Publisher
- S. Karger AG
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine); General Internal Medicine
- Web of Science ID
- WOS:000484667600040
- Scopus ID
- 2-s2.0-85070456843
- Other Identifier
- 991021860796004721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology