Journal article
A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature
Case reports in hematology, v 2017, pp 1-5
01 Jan 2017
PMID: 29082050
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. Despite immediate intravenous antimicrobial therapy and emergent fasciotomy with extensive debridement, his hospital course was complicated by septic shock and he required an above-the-knee amputation. Physicians need to be aware of the possibility of necrotizing fasciitis in patients presenting with skin infections after rituximab therapy.
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Details
- Title
- A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature
- Creators
- Abdullateef Abdulkareem - Reading HospitalRyan S. D'Souza - Mayo Clinic HospitalOluwaseun Shogbesan - Reading HospitalAnthony Donato - Reading Hospital
- Publication Details
- Case reports in hematology, v 2017, pp 1-5
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Web of Science ID
- WOS:000411607000001
- Other Identifier
- 991022161837304721
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- Web of Science research areas
- Hematology