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A Clinical Approach to Early-Onset Inheritable Dementia
Journal article   Open access   Peer reviewed

A Clinical Approach to Early-Onset Inheritable Dementia

Brian S. Rogers and Carol F. Lippa
American journal of Alzheimer's disease and other dementias, v 27(3), pp 154-161
01 May 2012
PMID: 22573281
url
https://doi.org/10.1177/1533317512444000View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze) Open

Abstract

Clinical Neurology Geriatrics & Gerontology Life Sciences & Biomedicine Neurosciences & Neurology Science & Technology
Early-onset dementia, presenting before age 65 years, is increasingly recognized. It is often difficult to diagnose, since non-Alzheimer's etiologies and unusual dementias are common. These conditions are more commonly genetic, and important potentially inherited causes of early-onset dementia include early-onset Alzheimer's disease, frontotemporal dementia, Kufs' disease, and Niemann-Pick disease type C. For each of these diseases, this review provides information on common clinical presentations, etiology, pathophysiology, and current and experimental treatments. A discussion of the diagnosis and workup for early-onset dementia is included with an emphasis on conditions that may have other involved family members.

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17 citations in Scopus

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Web of Science research areas
Clinical Neurology
Geriatrics & Gerontology
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