Journal article
A Clinical Consensus Statement on Pulmonary Recurrent Respiratory Papillomatosis
The Laryngoscope, v 135(12), pp 4642-4650
Dec 2025
PMID: 40747774
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective
Pulmonary recurrent respiratory papillomatosis (pRRP) is a rare manifestation of RRP with a paucity of data on workup and management. The objective was to develop guidance on the screening, diagnosis, and management of pRRP based on literature review and multidisciplinary expert consensus.
Methods
A pRRP expert group was assembled, comprising one representative from the RRP Foundation and 19 adult and pediatric otolaryngologists, thoracic surgeons, pulmonologists, oncologists, pathologists, and radiologists with experience in the management of pRRP. A rigorous Delphi method including video meetings and consensus surveys was used to establish consensus pertaining to screening, diagnosis, management, and treatment.
Results
After the literature review, the core working group created 33 statements regarding screening, diagnosis, management, and treatment. After distribution to the consensus group, three iterative surveys were performed, each followed by 90 min of live discussion. Consensus was achieved for screening (9 statements); diagnosis (6); management (4); treatment (11); and systemic treatment (3). Key statements include a recommendation for HPV typing at the time of diagnosis; chest CT to monitor disease progression; biopsy of suspected pulmonary lesions when possible; a multidisciplinary team for management; and consideration of systemic therapy.
Conclusion
pRRP is present in up to 9% of patients with RRP and carries a 32-fold increased risk of malignant transformation. Obtaining consensus on best practices can reduce variability in the treatment of orphan diseases and guide future research efforts. This statement reflects the efforts of a national group of dedicated experts with an established history in managing this difficult disease.
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Details
- Title
- A Clinical Consensus Statement on Pulmonary Recurrent Respiratory Papillomatosis
- Creators
- Nikita Kohli - Yale UniversitySara I. Pai - Yale UniversityJulia Buckingham - Palo Alto UniversityYvonne M. Carter - University of Nevada, Las VegasNabil F. Saba - Emory UniversityYin P. Hung - Massachusetts General HospitalDavid Berkowitz - Emory UniversitySimon R. Best - Johns Hopkins UniversityKara Davis - Palo Alto UniversityChristopher Morton - Yale UniversityJonathan Popler - Children's Healthcare of AtlantaSeth Pransky - HealthCare Partners Medical GroupJoseph Piccione - University of PennsylvaniaDavid F. Smith - Cincinnati Children's Hospital Medical CenterRajkumar Venkatramani - Baylor College of MedicineMarcelle Stiff - Recurrent Respiratory Papillomatosis Foundation, Orlando, FL, United StatesFarrel J. Buchinsky - Drexel University, Otolaryngology (and Head and Neck Surgery)Douglas R. Sidell - Palo Alto University
- Publication Details
- The Laryngoscope, v 135(12), pp 4642-4650
- Publisher
- Wiley
- Grant note
- Stanford Maternal and Child Health Research Institute RRP Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:001543078900001
- Scopus ID
- 2-s2.0-105012181398
- Other Identifier
- 991022068077104721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Otorhinolaryngology