Journal article
A Comparative Analysis of the Full and Short Versions of the Social Responsiveness Scale in Estimating an Established Autism Risk Factor Association in ECHO: Do we Get the Same Estimates?
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
22 Jul 2023
PMID: 37480437
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose Prior work developed a shortened 16-item version of the Social Responsiveness Scale (SRS), a quantitative measure of social communication and autism spectrum disorder (ASD)-related traits. However, its properties for use in risk factor estimation have not been fully tested compared to the full SRS. We compared the associations between gestational age (previously established risk factor for ASD) and the 65-item full and 16-item short versions of the SRS to test the shortened version's ability to capture associations in epidemiologic analyses of ASD risk factors.Methods We used data from participants in the Environmental influences on Child Health Outcomes (ECHO) Program (n = 2,760). SRS scores were collected via maternal/caregiver report when children were aged 2.5-18 years. We compared estimates of associations between gestational age and preterm birth between the full and short SRS using multivariable linear regression, quantile regression, and prediction methods.Results Overall, associations based on full and short SRS scores were highly comparable. For example, we observed positive associations between preterm birth with both full (=2.8; 95% CI [1.7, 4.0]) and short (=2.9; 95% CI [1.6, 4.3]) SRS scores. Quantile regression analyses indicated similar direction and magnitude of associations across the distribution of SRS scores between gestational age with both short and full SRS scores.Conclusion The comparability in estimates obtained for full and short SRS scores with an established ASD risk factor suggests ability of the shortened SRS in assessing associations with potential ASD-related risk factors and has implications for large-scale research studies seeking to reduce participant burden.
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Details
- Title
- A Comparative Analysis of the Full and Short Versions of the Social Responsiveness Scale in Estimating an Established Autism Risk Factor Association in ECHO: Do we Get the Same Estimates?
- Publication Details
- JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
- Publisher
- SPRINGER/PLENUM PUBLISHERS; NEW YORK
- Grant note
- Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health, under Award Number U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (PRO CORE) with co-funding from the Office of Behavioral and Social Science Research, 1U2COD023375-02 (Lyall), UH3OD023342 (Newschaffer & Lyall), UH3OD023275 (Karagas), UG3/UH3OD023365 (Hertz-Picciotto), 5UH3OD023348-04 (O'Shea), 1UG3OD023271-01 and 4UH3OD023271-03 (Karr), 1UG3OD023305-01 and 4UH3OD023305-03 (Trasande), UG3/UH3OD023328 (Duarte); UG3/UH3OD023286 (Oken), UG3/UH3OD023289 (Ferrara/Croen). Funding support for original data collections were also received from the NIH under R01MH068398 (Ozonoff), R01MH059630 (Landa), R01HD055741 (Piven); R01ES016863 (Swan), R01ES25169 (Swan); R24ES028533 (Schmidt), R01ES028089 (Hertz-Picciotto), R01ES020392 (Hertz-Picciotto, Ozonoff, Pessah), P01ES011269 (Hertz-Picciotto, Pessah) from the National Institute of Environmental Health Sciences under P01ES022832 and US EPA US EPA: RD83544201 (Karagas), RD-83329201 (Pessah); and grants and from the National Institute of Child Health and Human Development under R01HD057284 (Messinger and Stone).
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001035769700002
- Scopus ID
- 2-s2.0-85165572314
- Other Identifier
- 991021861183904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychology, Developmental