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Journal article
A Comparative Classification Analysis of Abdominal Aortic Aneurysms by Machine Learning Algorithms
Annals of biomedical engineering, v 48(4), pp 1419-1429
01 Apr 2020
PMID: 31980998
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The objective of this work was to perform image-based classification of abdominal aortic aneurysms (AAA) based on their demographic, geometric, and biomechanical attributes. We retrospectively reviewed existing demographics and abdominal computed tomography angiography images of 100 asymptomatic and 50 symptomatic AAA patients who received an elective or emergent repair, respectively, within 1-6 months of their last follow up. An in-house script developed within the MATLAB computational platform was used to segment the clinical images, calculate 53 descriptors of AAA geometry, and generate volume meshes suitable for finite element analysis (FEA). Using a third party FEA solver, four biomechanical markers were calculated from the wall stress distributions. Eight machine learning algorithms (MLA) were used to develop classification models based on the discriminatory potential of the demographic, geometric, and biomechanical variables. The overall classification performance of the algorithms was assessed by the accuracy, area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and precision of their predictions. The generalized additive model (GAM) was found to have the highest accuracy (87%), AUC (89%), and sensitivity (78%), and the third highest specificity (92%), in classifying the individual AAA as either asymptomatic or symptomatic. The k-nearest neighbor classifier yielded the highest specificity (96%). GAM used seven markers (six geometric and one biomechanical) to develop the classifier. The maximum transverse dimension, the average wall thickness at the maximum diameter, and the spatially averaged wall stress were found to be the most influential markers in the classification analysis. A second classification analysis revealed that using maximum diameter alone results in a lower accuracy (79%) than using GAM with seven geometric and biomechanical markers. We infer from these results that biomechanical and geometric measures by themselves are not sufficient to discriminate adequately between population samples of asymptomatic and symptomatic AAA, whereas MLA offer a statistical approach to stratification of rupture risk by combining demographic, geometric, and biomechanical attributes of patient-specific AAA.
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Details
- Title
- A Comparative Classification Analysis of Abdominal Aortic Aneurysms by Machine Learning Algorithms
- Creators
- Balaji Rengarajan - The University of Texas at San AntonioWei Wu - The University of Texas at San AntonioCrystal Wiedner - The University of Texas at San AntonioDaijin Ko - The University of Texas at San AntonioSatish C. Muluk - Allegheny General HospitalMark K. Eskandari - Northwestern UniversityPrahlad G. Menon - Carlow UniversityEnder A. Finol - The University of Texas at San Antonio
- Publication Details
- Annals of biomedical engineering, v 48(4), pp 1419-1429
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- R01HL121293 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiothoracic Surgery
- Web of Science ID
- WOS:000509147100002
- Scopus ID
- 2-s2.0-85078094736
- Other Identifier
- 991021944493104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical