Journal article
A Comparative Study of the Electrophysiologic Effects of Striadyne, Adenosine Triphosphate and Adenosine in the Canine Heart
Cardiology, v 72(3), pp 113-122
1985
PMID: 3995515
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The chronotropic and dromotropic effects of the intra-atrial administration of 0.97, 1.93 and 2.90µM/kg Striadyne, the pharmaceutical form of adenosine triphosphate (ATP) for clinical use, ATP, and adenosine, were compared in 13 anesthetized dogs. Striadyne, ATP and adenosine exerted transient dose-dependent negative chronotropic and dromotropic effects. There was no significant difference between the electrophysiologic effects of Striadyne and ATP which were significantly more pronounced than those of adenosine. Atro-pine (0.2 mg/kg) significantly attenuated the electrophysiologic effects of 2.90 µM/kg Striadyne and ATP but not those of adenosine. It is concluded that Striadyne and ATP have similar electrophysiologic effects which are more pronounced than those of adenosine mainly due to vagal involvement in their mechanism of action.
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Details
- Title
- A Comparative Study of the Electrophysiologic Effects of Striadyne, Adenosine Triphosphate and Adenosine in the Canine Heart
- Creators
- Bernard BelhassenReuben IliaAmir PellegAllan GreenspanLeonard Horowitz
- Publication Details
- Cardiology, v 72(3), pp 113-122
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:A1985AGM7800002
- Scopus ID
- 2-s2.0-0021809021
- Other Identifier
- 991019348913304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems