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A Comparison Between W Score and RYAN Score in Diagnosing Laryngopharyngeal Reflux Disease
Journal article   Open access   Peer reviewed

A Comparison Between W Score and RYAN Score in Diagnosing Laryngopharyngeal Reflux Disease

Gang Wang, Lei Wang, Zhezhe Sun, Lianyong Li, Yuzhu Guo, Jimin Wu, Qi Wang, Jugao Fang, Qiuping Lv, Gelin Li, …
Journal of voice
08 Jul 2023
DOI: https://doi.org/10.1016/j.jvoice.2023.06.001
PMID: 37429810
url
https://doi.org/10.21203/rs.3.rs-409806/v1View
SubmittedOpen Access (License Unspecified),  Open

Abstract

Laryngopharyngeal reflux Pharyngeal pH monitoring Restech RYAN score W score
To assess the diagnostic value of the W score in differentiating laryngopharyngeal reflux disease (LPRD) patients from the normal population by pharyngeal pH (Dx-pH) monitoring, compared with the RYAN score. One hundred and eight patients with suspected LPRD and complete follow-up results after more than 8 weeks of anti-reflux therapy were enrolled from the Department of Otolaryngology—Head and Neck Surgery, Gastroenterology and Respiratory Medicine of seven hospitals. Their Dx-pH monitoring data before treatment were reanalyzed to obtain the W score in addition to the RYAN score and then the diagnostic sensitivity and specificity were compared and evaluated with reference to the result of anti-reflux therapy. In eighty-seven (80.6%) cases, anti-reflux therapy was effective, and in 21 patients (19.4%), therapy was ineffective. Twenty-seven patients (25.0%) had a positive RYAN score. The W score was positive in 79 (73.1%) patients. There were 52 patients who had a negative RYAN score, but a positive W score. The diagnostic sensitivity, specificity, positive predictive value, and negative predictive value of the RYAN score were 28.7%, 90.5%, 92.6%, and 23.5%, respectively (kappa = 0.092, P = 0.068), whereas those of the W score for LPRD was 83.9%, 71.4%, 92.4%, and 51.7%, respectively (kappa = 0.484, P < 0.001). W score is much more sensitive for the diagnosis of LPRD. Prospective studies with larger patient populations are necessary to validate and improve diagnostic efficacy. Chinese Clinical Trial Registry: ChiCTR1800014931.

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