Journal article
A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing
Molecules (Basel, Switzerland), v 23(1)
01 Jan 2018
PMID: 29278360
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Catecholamines play an important regulatory role in cutaneous wound healing. The exact role of dopamine in human epidermis has yet to be fully elucidated. Current published evidence describes its differential effects on two separate families of G protein coupled receptors: D1-like and D2-like dopamine receptors. Dopamine may enhance angiogenesis and wound healing through its action on dopamine D1 receptors, while impairing wound healing when activating D2 receptors. This review summarizes the evidence for the role of dopamine in wound healing and describes potential mechanisms behind its action on D1 versus D2-like receptors in the skin.
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Details
- Title
- A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing
- Creators
- Alexandra R. Vaughn - Drexel UniversityMichael James Davis - Emory UniversityRaja K. Sivamani - California State University, SacramentoRoslyn Rivkah Isseroff - University of California, Davis
- Publication Details
- Molecules (Basel, Switzerland), v 23(1)
- Publisher
- Mdpi
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000425082500047
- Scopus ID
- 2-s2.0-85039799251
- Other Identifier
- 991019357773304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary