Journal article
A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila
Nature communications, v 10(1), pp 4796-17
2019
PMID: 31641138
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Interneurons (INs) coordinate motoneuron activity to generate appropriate patterns of muscle contractions, providing animals with the ability to adjust their body posture and to move over a range of speeds. In Drosophila larvae several IN subtypes have been morphologically described and their function well documented. However, the general lack of molecular characterization of those INs prevents the identification of evolutionary counterparts in other animals, limiting our understanding of the principles underlying neuronal circuit organization and function. Here we characterize a restricted subset of neurons in the nerve cord expressing the Maf transcription factor Traffic Jam (TJ). We found that TJ+ neurons are highly diverse and selective activation of these different subtypes disrupts larval body posture and induces specific locomotor behaviors. Finally, we show that a small subset of TJ+ GABAergic INs, singled out by the expression of a unique transcription factors code, controls larval crawling speed.
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Details
- Title
- A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila
- Creators
- H. Babski - Institute for Neurosciences of MontpellierTihana Jovanic - Institut des Neurosciences Paris-SaclayC. Surel - Institute for Neurosciences of MontpellierS. Yoshikawa - Salk Institute for Biological StudiesM. Zwart - University of St AndrewsJ. Valmier - Institute for Neurosciences of MontpellierJ. Thomas - Salk Institute for Biological StudiesJ. Enriquez - Institut de Génomique Fonctionnelle de LyonP. Carroll - Institute for Neurosciences of MontpellierA. Garces - Institut de Génomique Fonctionnelle de Lyon
- Publication Details
- Nature communications, v 10(1), pp 4796-17
- Publisher
- Nature Publishing Group
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000491306200004
- Scopus ID
- 2-s2.0-85073731880
- Other Identifier
- 991019415773804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences