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Journal article
A Genome-Wide Association Study of Depressive Symptoms
Biological psychiatry (1969), v 73(7), pp 667-678
01 Apr 2013
PMCID: PMC3845085
PMID: 23290196
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Abstract
Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms.
In this genome-wide association study, we combined the results of 17 population-based studies assessing depressive symptoms with the Center for Epidemiological Studies Depression Scale. Replication of the independent top hits (p<1×10−5) was performed in five studies assessing depressive symptoms with other instruments. In addition, we performed a combined meta-analysis of all 22 discovery and replication studies.
The discovery sample comprised 34,549 individuals (mean age of 66.5) and no loci reached genome-wide significance (lowest p = 1.05×10−7). Seven independent single nucleotide polymorphisms were considered for replication. In the replication set (n = 16,709), we found suggestive association of one single nucleotide polymorphism with depressive symptoms (rs161645, 5q21, p = 9.19×10−3). This 5q21 region reached genome-wide significance (p = 4.78×10−8) in the overall meta-analysis combining discovery and replication studies (n = 51,258).
The results suggest that only a large sample comprising more than 50,000 subjects may be sufficiently powered to detect genes for depressive symptoms.
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- Title
- A Genome-Wide Association Study of Depressive Symptoms
- Creators
- Karin Hek - Erasmus University RotterdamAyse Demirkan - Erasmus University RotterdamJari Lahti - Florida State UniversityAntonio Terracciano - National Institutes of HealthAlexander Teumer - Universitätsmedizin GreifswaldMarilyn C. Cornelis - Harvard UniversityNajaf Amin - Erasmus University RotterdamErin Bakshis - University of Michigan–Ann ArborJens Baumert - Helmholtz Zentrum MünchenJingzhong Ding - Wake Forest UniversityYongmei Liu - Wake Forest UniversityKristin Marciante - University of WashingtonOsorio Meirelles - National Institutes of HealthMichael A. Nalls - National Institute on AgingYan V. Sun - Emory UniversityNicole Vogelzangs - Vrije Universiteit AmsterdamLei Yu - Rush University Medical CenterStefania Bandinelli - Azienda Sanitaria di FirenzeEmelia J. Benjamin - Boston UniversityDavid A. Bennett - Rush University Medical CenterDorret Boomsma - Vrije Universiteit AmsterdamAlessandra Cannas - GeneTiCALaura H. Coker - Wake Forest UniversityEco de Geus - VU University AmsterdamPhilip L. De Jager - Harvard UniversityAna V. Diez-Roux - University of Michigan–Ann ArborShaun Purcell - Harvard UniversityFrank B. Hu - Harvard UniversityEric B. Rimm - Harvard UniversityDavid J. Hunter - Harvard UniversityMajken K. Jensen - Harvard UniversityGary Curhan - Harvard UniversityKenneth Rice - University of WashingtonAlan D. Penman - University of MississippiJerome I. Rotter - Cedars-Sinai Medical CenterNona Sotoodehnia - University of WashingtonRebecca Emeny - Helmholtz Zentrum MünchenJohan G. ErikssonDenis A. Evans - Rush University Medical CenterLuigi Ferrucci - National Institutes of HealthMyriam Fornage - The University of Texas Health Science Center at HoustonVilmundur Gudnason - University of IcelandAlbert Hofman - Erasmus University RotterdamThomas Illig - Medizinische Hochschule HannoverSharon Kardia - Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MichiganMargaret Kelly-Hayes - Boston UniversityKarestan Koenen - Columbia UniversityPeter Kraft - Harvard UniversityMaris Kuningas - Erasmus University RotterdamJoseph M. Massaro - Boston UniversityDavid Melzer - University of ExeterAntonella Mulas - GeneTiCACornelis L. Mulder - Erasmus University RotterdamAnna Murray - University of ExeterBen A. Oostra - Erasmus University RotterdamAarno Palotie - Wellcome Sanger InstituteBrenda Penninx - EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The NetherlandsAstrid Petersmann - Universitätsmedizin GreifswaldLuke C. Pilling - University of ExeterBruce Psaty - Kaiser Permanente Washington Health Research InstituteRajesh Rawal - Helmholtz Zentrum MünchenEric M. Reiman - Translational Genomics Research InstituteAndrea Schulz - Universitätsmedizin GreifswaldJoshua M. Shulman - Baylor College of MedicineAndrew B. Singleton - National Institutes of HealthAlbert V. Smith - University of IcelandAngelina R. Sutin - Florida State UniversityAndré G. Uitterlinden - Erasmus University RotterdamHenry Völzke - Universitätsmedizin GreifswaldElisabeth Widen - University of HelsinkiKristine Yaffe - University of California, San FranciscoAlan B. Zonderman - National Institutes of HealthFrancesco Cucca - GeneTiCATamara Harris - National Institutes of HealthKarl-Heinz Ladwig - Helmholtz Zentrum MünchenDavid J. Llewellyn - University of ExeterKatri Räikkönen - University of HelsinkiToshiko Tanaka - National Institutes of HealthCornelia M. van Duijn - Erasmus University RotterdamHans J. Grabe - Universitätsmedizin GreifswaldLenore J. Launer - National Institutes of HealthKathryn L. Lunetta - Boston UniversityThomas H. Mosley - University of MississippiAnne B. Newman - University of PittsburghHenning Tiemeier - Erasmus University RotterdamJoanne Murabito - Boston University
- Publication Details
- Biological psychiatry (1969), v 73(7), pp 667-678
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Drexel University
- Web of Science ID
- WOS:000316685400013
- Scopus ID
- 2-s2.0-84875211424
- Other Identifier
- 991020099057004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Psychiatry