Journal article
A Hardwired Circuit Supplemented with Endocannabinoids Encodes Behavioral Choice in Zebrafish
Current biology, v 25(20), pp 2610-2620
19 Oct 2015
PMID: 26412127
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Animals constantly make behavioral choices to facilitate moving efficiently through their environment. When faced with a threat, animals make decisions in the midst of other ongoing behaviors through a context-dependent integration of sensory stimuli. In vertebrates, the mechanisms underlying behavioral selection are poorly understood. Here, we show that ongoing swimming in zebrafish is suppressed by escape. The selection of escape over swimming is mediated by switching between two distinct motoneuron pools. A hardwired circuit mediates this switch by acting as a clutch-like mechanism to disengage the swimming motoneuron pool and engage the escape motoneuron pool. Threshold for escape initiation is lowered and swimming suppression is prolonged by endocannabinoid neuromodulation. Thus, our results reveal a novel cellular mechanism involving a hardwired circuit supplemented with endocannabinoids acting as a clutch-like mechanism to engage/disengage distinct motor pools to ensure behavioral selection and a smooth execution of motor action sequences in a vertebrate system.
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Details
- Title
- A Hardwired Circuit Supplemented with Endocannabinoids Encodes Behavioral Choice in Zebrafish
- Creators
- Jianren Song - Karolinska InstitutetKonstantinos Ampatzis - Karolinska InstitutetJessica Ausborn - Karolinska InstitutetAbdeljabbar El Manira - Karolinska Institutet
- Publication Details
- Current biology, v 25(20), pp 2610-2620
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- Swedish Brain Foundation Karolinska Institute; Karolinska Institutet Swedish Research Council; Swedish Research Council for Health Working Life & Welfare (Forte); Swedish Research Council Formas StratNeuro
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000363359500018
- Scopus ID
- 2-s2.0-84945565818
- Other Identifier
- 991020655668704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biology
- Cell Biology