Journal article
A Highly Sensitive and Long-Term Stable Wearable Patch for Continuous Analysis of Biomarkers in Sweat
Advanced functional materials, v 33(52), 2306117
22 Dec 2023
PMID: 38525448
Abstract
Although increasing efforts have been devoted to the development of non-invasive wearable electrochemical sweat sensors for monitoring physiological and metabolic information, most of them still suffer from poor stability and specificity over time and fluctuating temperatures. This study reports the design and fabrication of a long-term stable and highly sensitive flexible electrochemical sensor based on nanocomposite-modified porous graphene by facile laser treatment for detecting biomarkers such as glucose in sweat. The laser-reduced and patterned stable conductive nanocomposite on the porous graphene electrode provides the resulting glucose sensor with an excellent sensitivity of 1317.69 & mu;A mm-1 cm-2 and an ultra-low limit of detection of 0.079 & mu;m. The sensor can also detect pH and exhibit extraordinary stability to maintain more than 91% sensitivity over 21 days in ambient conditions. Taken together with a temperature sensor based on the same material system, the dual glucose and pH sensor integrated with a flexible microfluidic sweat sampling network further results in accurate continuous on-body glucose detection calibrated by the simultaneously measured pH and temperature. The low-cost, highly sensitive, and long-term stable platform could facilitate the early identification and continuous monitoring of different biomarkers for non-invasive disease diagnosis and treatment evaluation.
This study reports the design and fabrication of a long-term stable and highly sensitive flexible electrochemical sensor based on nanocomposite-modified porous graphene by simple and facile laser treatment for detecting biomarkers such as sweat glucose with an excellent sensitivity and an ultra-low limit of detection.image
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Details
- Title
- A Highly Sensitive and Long-Term Stable Wearable Patch for Continuous Analysis of Biomarkers in Sweat
- Creators
- Farnaz Lorestani - Pennsylvania State UniversityXianzhe Zhang - Pennsylvania State UniversityAbu Musa Abdullah - Pennsylvania State UniversityXin Xin - Pennsylvania State UniversityYushen Liu - Pennsylvania State UniversityMd Mashfiqur Rahman - Pennsylvania State UniversityMd Abu Sayeed Biswas - Pennsylvania State UniversityBowen Li - Pennsylvania State UniversityAnkan Dutta - Pennsylvania State UniversityZhenyuan Niu - Pennsylvania State UniversityShuvendu Das - Pennsylvania State UniversityShishir Barai - Pennsylvania State UniversityKe Wang - Pennsylvania State UniversityHuanyu Cheng - Pennsylvania State University
- Publication Details
- Advanced functional materials, v 33(52), 2306117
- Publisher
- Wiley
- Number of pages
- 12
- Grant note
- ECCS-1933072; 2222654; 2309323 / National Science Foundation (NSF) Penn State University; Pennsylvania State University R21EB030140; R21OH012220; R33HL154215; T32NS115667 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Leighton Riess Graduate Fellowship at Penn State University; Pennsylvania State University
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:001064832200001
- Scopus ID
- 2-s2.0-85170686807
- Other Identifier
- 991022094538904721