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Journal article
A Little Help From the Follicles: Understanding the Germinal Center Response to Human Immunodeficiency Virus 1 Infection and Prophylactic Vaccines
Clinical medicine insights. Pathology, v 10(10), pp 1179555717695548-1179555717695548
30 Mar 2017
PMID: 28469517
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human immunodeficiency virus 1 (HIV-1) is the causative agent of AIDS. There are currently more than 35 million people living with HIV infection worldwide, and more than 2 million new infections occur each year. The global pandemic caused by HIV-1 is the subject of numerous research projects, with the development of a prophylactic vaccine and a therapeutic cure being the ultimate goals. The classic paradigms of vaccinology have proven incapable of producing a viable vaccine due to the complexity of the virus’ replication cycle, its genetic diversity, and a lack of understanding of the immune correlates of protection. Here, we briefly discuss recent vaccine approaches and the immune correlates of protection from HIV-1 infection with a focus on the role of the germinal center as a reservoir of replication-competent virus and its role in the development of broadly neutralizing antibodies in response to vaccination.
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Details
- Title
- A Little Help From the Follicles: Understanding the Germinal Center Response to Human Immunodeficiency Virus 1 Infection and Prophylactic Vaccines
- Creators
- Ebony N Gary - Drexel UniversityMichele A Kutzler - Drexel University
- Publication Details
- Clinical medicine insights. Pathology, v 10(10), pp 1179555717695548-1179555717695548
- Publisher
- SAGE Publications
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000397628900001
- Scopus ID
- 2-s2.0-85044506593
- Other Identifier
- 991019167769504721
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- Web of Science research areas
- Pathology