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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
A Multicenter Analysis of Elvitegravir Use During Pregnancy on HIV Viral Suppression and Perinatal Outcomes
Open forum infectious diseases, v 6(4), pp ofz129-ofz129
01 Apr 2019
PMID: 31037241
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background. There is a knowledge gap on the clinical use of elvitegravir (EVG) during pregnancy and maternal viral suppression. Our objective was to evaluate the effects of EVG use in pregnancy on rates of HIV virologic suppression and perinatal outcomes.
Methods. We conducted a retrospective, multicenter study of pregnant women living with HIV (WLHIV) who used EVG-containing antiretroviral therapy (ART) between January 2014 and March 2017 at 9 tertiary care centers in the United States. WLHIV were included if they took EVG at any time during pregnancy. We described the characteristics of the WLHIV using EVG during the study period and evaluated the rates of HIV suppression and perinatal outcomes.
Results. Among 134 pregnant WLHIV who received EVG at any time during pregnancy, viral suppression at delivery (HIV-1 RNA < 40 copies/mL) occurred in 81.3%. In WLHIV who initiated EVG before pregnancy and continued through delivery (n = 68), the rate of viral suppression at delivery was 88.2%. The average gestational age at the time of delivery was 37 weeks 6 days, and the overall rate of preterm birth was 20%. No cases of open neural tube defects were noted in women on EVG at the time of conception (n = 82). The perinatal HIV transmission rate was 0.8%.
Conclusions. EVG use was associated with high sustained levels of HIV suppression during pregnancy and a low rate of perinatal HIV transmission.
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Details
- Title
- A Multicenter Analysis of Elvitegravir Use During Pregnancy on HIV Viral Suppression and Perinatal Outcomes
- Creators
- Martina L. Badell - Emory UniversityAnandi N. Sheth - Emory UniversityFlorence Momplaisir - Drexel UniversityLisa Rahangdale - University of North Carolina at Chapel HillJoNell Potter - University of MiamiPadmashree C. Woodham - Mercer University Health Sciences CenterGweneth B. Lazenby - Medical University of South CarolinaWilliam R. Short - University of PennsylvaniaScott E. Gillespie - Emory UniversityNevert Baldreldin - Northwestern UniversityEmily S. Miller - Northwestern UniversityGregg Alleyne - Drexel UniversityLunthita M. Duthely - University of MiamiStephanie M. Allen - Baylor College of MedicineJudy Levison - Baylor College of MedicineRana Chakraborty - Mayo ClinicHOPES HIV OB Pregnancy Educ Study
- Publication Details
- Open forum infectious diseases, v 6(4), pp ofz129-ofz129
- Publisher
- Oxford Univ Press
- Number of pages
- 7
- Grant note
- KL2 TR002737 / NCATS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) KL2TR002737 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000474844200040
- Scopus ID
- 2-s2.0-85066398920
- Other Identifier
- 991019167921404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology