Journal article
A Multifunctional 3D Bioprinting System for Construction of Complex Tissue Structure Scaffolds: Design and Application
INTERNATIONAL JOURNAL OF BIOPRINTING, v 8(4), 617
2022
PMID: 36404789
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Three-dimensional (3D) bioprinting offers a potentially powerful new approach to reverse engineering human pathophysiology to address the problem of developing more biomimetic experimental systems. Human tissues and organs are multiscale and multi-material structures. The greatest challenge for organ printing is the complexity of the structural elements, from the shape of the macroscopic structure to the details of the nanostructure. A highly bionic tissue-organ model requires the use of multiple printing processes. Some printers with multiple nozzles and multiple processes are currently reported. However, the bulk volume, which is inconvenient to move, and the high cost of these printing systems limits the expansion of their applications. Scientists urgently need a multifunctional miniaturized 3D bioprinter. In this study, a portable multifunctional 3D bioprinting system was built based on a modular design and a custom written operating application. Using this platform, constructs with detailed surface structures, hollow structures, and multiscale complex tissue analogs were successfully printed using commercial polymers and a series of hydrogel-based inks. With further development, this portable, modular, low-cost, and easy-to-use Bluetooth-enabled 3D printer promises exciting opportunities for resource-constrained application scenarios, not only in biomedical engineering but also in the education field, and may be used in space experiments.
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Details
- Title
- A Multifunctional 3D Bioprinting System for Construction of Complex Tissue Structure Scaffolds: Design and Application
- Publication Details
- INTERNATIONAL JOURNAL OF BIOPRINTING, v 8(4), 617
- Publisher
- WHIOCE PUBL PTE LTD; SINGAPORE
- Grant note
- Funding National Key Research and Development Program of China (2018YFA0703004) .
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000856208700001
- Scopus ID
- 2-s2.0-85140645992
- Other Identifier
- 991021861301304721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials