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Accepted (AM)Open Access (License Unspecified), Open
Journal article
A Pooled Analysis of Alcohol Consumption and Risk of Multiple Myeloma in the International Multiple Myeloma Consortium
Cancer epidemiology, biomarkers & prevention, v 22(9), pp 1620-1627
01 Sep 2013
PMID: 23964064
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Recent findings suggest that alcohol consumption may reduce risk of multiple myeloma.
Methods: To better understand this relationship, we conducted an analysis of six case-control studies participating in the International Multiple Myeloma Consortium (1,567 cases, 7,296 controls). Summary ORs and 95% confidence intervals (CI) relating different measures of alcohol consumption and multiple myeloma risk were computed by unconditional logistic regression with adjustment for age, race, and study center.
Results: Cases were significantly less likely than controls to report ever drinking alcohol (men: OR = 0.72; 95% CI, 0.59-0.89; women: OR = 0.81; 95% CI, 0.68-0.95). The inverse association with multiple myeloma was stronger when comparing current to never drinkers (men: OR = 0.57; 95% CI, 0.45-0.72; women: OR = 0.55; 95% CI, 0.45-0.68), but null among former drinkers. We did not observe an exposure-response relationship with increasing alcohol frequency, duration, or cumulative lifetime consumption. Additional adjustment for body mass index, education, or smoking did not affect our results; and the patterns of association were similar for each type of alcohol beverage examined.
Conclusions: Our study is, to our knowledge, the largest of its kind to date, and our findings suggest that alcohol consumption may be associated with reduced risk of multiple myeloma.
Impact: Prospective studies, especially those conducted as pooled analyses with large sample sizes, are needed to confirm our findings and further explore whether alcohol consumption provides true biologic protection against this rare, highly fatal malignancy. (C) 2013 AACR.
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Details
- Title
- A Pooled Analysis of Alcohol Consumption and Risk of Multiple Myeloma in the International Multiple Myeloma Consortium
- Creators
- Gabriella Andreotti - United States Department of Health and Human ServicesBrenda Birmann - Harvard UniversityAnneclaire J. De Roos - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaJohn Spinelli - University of British ColumbiaWendy Cozen - University of Southern CaliforniaNicola J. Camp - University of UtahKirsten Moysich - Roswell Park Cancer InstituteBrian Chiu - University of ChicagoEmily Steplowski - Information Management ServicesJoseph Krzystan - Information Management ServicesPaolo Boffetta - International Prevention Research InstituteVeronique Benhaim-Luzon - Centre international de recherche sur le cancerPaul Brennan - Centre international de recherche sur le cancerSilvia de Sanjose - Universitat de BarcelonaLaura Costas - McGill UniversityAdele Seniori Costantini - Istituto per lo Studio e la Prevenzione OncologicaLucia Miligi - Istituto per lo Studio e la Prevenzione OncologicaPierluigi Cocco - University of CagliariNikolaus Becker - German Cancer Research CenterLenka Foretova - Masaryk Memorial Cancer InstituteMarc Maynadie - Université de BourgogneAlexandra Nieters - German Cancer Research CenterAnthony Staines - University College DublinGuido Tricot - University of IowaKevin Milliken - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaDennis Weisenburger - University of Nebraska Medical CenterTongzhang Zheng - Yale UniversityDalsu Baris - National Institutes of HealthMark P. Purdue - National Institutes of Health
- Publication Details
- Cancer epidemiology, biomarkers & prevention, v 22(9), pp 1620-1627
- Publisher
- Amer Assoc Cancer Research
- Number of pages
- 8
- Grant note
- HHSN261201000026C / NCI SEER; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) HCI Cancer Center Utah State Department of Health 6067-09 / Leukemia and Lymphoma Society University of Utah CZ.1.05/2.1.00/03.0101 / State Budget of the Czech Republic (RECAMO) European Regional Development Fund; European Commission R21CA152336 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) CA152336; P30 CA42014; K07 CA115687; CA149445 / NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) RSG-11-020-01-CNE / American Cancer Society
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000324674500015
- Scopus ID
- 2-s2.0-84884149081
- Other Identifier
- 991020099716104721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health