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Accepted (AM)Open Access (License Unspecified), Open
Journal article
A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium
Cancer epidemiology, biomarkers & prevention, v 25(1), pp 217-221
01 Jan 2016
PMID: 26464426
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Female sex hormones are known to have immunomodulatory effects. Therefore, reproductive factors and exogenous hormone use could influence the risk of multiple myeloma in women. However, the role of hormonal factors in multiple myeloma etiology remains unclear because previous investigations were underpowered to detect modest associations.
Methods: We conducted a pooled analysis of seven case-control studies included in the International Multiple Myeloma Consortium, with individual data on reproductive factors and exogenous hormone use from 1,072 female cases and 3,541 female controls. Study-specific odds ratios and corresponding 95% confidence intervals (CI) were estimated using logistic regression and pooled analyses were conducted using random effects meta-analyses.
Results: Multiple myeloma was not associated with reproductive factors, including ever parous [OR = 0.92; 95% confidence interval (CI), 0.68-1.25], or with hormonal contraception use (OR = 1.04; 95% CI, 0.80-1.36). Postmenopausal hormone therapy users had nonsignificantly reduced risks of multiple myeloma compared with never users, but this association differed across centers (OR = 0.65; 95% CI, 0.37-1.15, I-2 = 76.0%, P-heterogeneity = 0.01).
Conclusions: These data do not support a role for reproductive factors or exogenous hormones in myelomagenesis.
Impact: Incidence rates of multiple myeloma are higher in men than in women, and sex hormones could influence this pattern. Associations with reproductive factors and exogenous hormone use were inconclusive despite our large sample size, suggesting that female sex hormones may not play a significant role in multiple myeloma etiology. (C) 2015 AACR.
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Details
- Title
- A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium
- Creators
- Laura Costas - University of BarcelonaBrice H. Lambert - University of Alabama at BirminghamBrenda M. Birmann - Brigham and Women's HospitalKirsten B. Moysich - Roswell Park Cancer InstituteAnneclaire J. De Roos - Drexel UniversityJonathan N. Hofmann - United States Department of Health and Human ServicesDalsu Baris - United States Department of Health and Human ServicesSophia S. Wang - Beckman Research InstituteNicola J. Camp - Huntsman Cancer InstituteGuido Tricot - University of IowaDjordje Atanackovic - Huntsman Cancer InstitutePaul Brennan - International Agency For Research On CancerPierluigi Cocco - University of CagliariAlexandra Nieters - University Medical Center FreiburgNikolaus Becker - German Cancer Research CenterMarc Maynadie - University of BurgundyLenka Foretova - Masaryk Memorial Cancer InstitutePaolo Boffetta - Icahn School of Medicine at Mount SinaiAnthony Staines - University College DublinElisabeth E. Brown - University of Alabama at BirminghamSilvia De Sanjose - University of Barcelona
- Publication Details
- Cancer epidemiology, biomarkers & prevention, v 25(1), pp 217-221
- Publisher
- Amer Assoc Cancer Research
- Number of pages
- 5
- Grant note
- P30 CA42014 / HCI Cancer Center Support grant from the NCI University of Utah CA152336; K07 CA115687; R01 CA127435; R01 CA149445; U54CA118948; R21CA155951; R25CA76023; R01CA186646 / NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) HHSN261201000026C / NCI SEER program P30CA13148 / University of Alabama at Birmingham Comprehensive Cancer Center Support Grant RSG-11-020-01-CNE; IRG60-001-47 / American Cancer Society IARC-5111 / International Agency for Research on Cancer 11855 / Italian Association for Cancer Research (AIRC); Fondazione AIRC per la ricerca sul cancro 00209805 / MH CZ - DRO (MMCI) 1999 008471 / Fondation de France Intramural Research Program of the NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA FOOD-CT-2006-023103 / European Commission 6th Framework Programme; European Commission; European Commission Joint Research Centre University of Utah Huntsman Cancer Institute (HCI) StSch4261; StSch4420 / German Federal Office for Radiation Protection QLK4-CT-2000-00422 / European Commission 5th Framework Programme; European Commission Rio Hortega CM13/00232; M-AES MV15/00025; PI11/01810; PI14/01219 / Spanish Ministry of Economy and Competitiveness - Carlos III Institute of Health U54CA118948 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01CA036388; R01CA077398; K05CA136967 / federal funds from the NCI, NIH 2007WEJLZB; 20092ZELR2 / Italian Ministry of Education, University and Research, PRIN programme; Ministry of Education, Universities and Research (MIUR) 051210 / Marato TV3 Foundation Utah State Department of Health 6067-09 / Leukemia and Lymphoma Society 2014SGR756 / Catalan Government University of Barcelona P30CA033572 / City of Hope Comprehensive Cancer Center Support Grant CZ.1.05/2.1.00/03.0101 / RECAMO FIS PI081555; RCESP C03/09; RTICESP C03/10; RTICRD06/0020/0095 / Carlos III Institute of Health; Instituto de Salud Carlos III
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000372171400029
- Scopus ID
- 2-s2.0-84955294772
- Other Identifier
- 991019169787004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health