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Journal article
A Pro-social Pill? The Potential of Pharmacological Treatments to Improve Social Outcomes After Pediatric Traumatic Brain Injury
Frontiers in neurology, v 12, pp 714253-714253
19 Aug 2021
PMID: 34489853
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Traumatic brain injury (TBI) is a leading cause of injury-induced disability in young children worldwide, and social behavior impairments in this population are a significant challenge for affected patients and their families. The protracted trajectory of secondary injury processes triggered by a TBI during early life-alongside ongoing developmental maturation-offers an extended time window when therapeutic interventions may yield functional benefits. This mini-review explores the scarce but promising pre-clinical literature to date demonstrating that social behavior impairments after early life brain injuries can be modified by drug therapies. Compounds that provide broad neuroprotection, such as those targeting neuroinflammation, oxidative stress, axonal injury and/or myelination, may prevent social behavior impairments by reducing secondary neuropathology. Alternatively, targeted treatments that promote affiliative behaviors, exemplified by the neuropeptide oxytocin, may reduce the impact of social dysfunction after pediatric TBI. Complementary literature from other early life neurodevelopmental conditions such as hypoxic ischemic encephalopathy also provides avenues for future research in neurotrauma. Knowledge gaps in this emerging field are highlighted throughout, toward the goal of accelerating translational research to support optimal social functioning after a TBI during early childhood.
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Details
- Title
- A Pro-social Pill? The Potential of Pharmacological Treatments to Improve Social Outcomes After Pediatric Traumatic Brain Injury
- Creators
- Bridgette D. Semple - Royal Melbourne HospitalRamesh Raghupathi - Drexel University
- Publication Details
- Frontiers in neurology, v 12, pp 714253-714253
- Publisher
- Frontiers Media S.A.
- Number of pages
- 9
- Grant note
- Monash University Central Clinical School APP1141347 / National Health and Medical Research Council of Australia W81XWH2010848 / United States Department of Defense R01 NS110898 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA SAP 410-007-9710; SAP 410-007-7079 / Commonwealth Universal Research Enhancement from the Pennsylvania Department of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000690455800005
- Scopus ID
- 2-s2.0-85114307831
- Other Identifier
- 991019167893804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences