Journal article
A Probiotic Mixture Induces Anxiolytic- and Antidepressive-Like Effects in Fischer and Maternally Deprived Long Evans Rats
Frontiers in behavioral neuroscience, v 14, pp 581296-581296
12 Nov 2020
PMID: 33312120
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A role of the gut microbiota in psychiatric disorders is supported by a growing body of literature. The effects of a probiotic mixture of four bacterial strains were studied in two models of anxiety and depression, naturally stress-sensitive Fischer rats and Long Evans rats subjected to maternal deprivation. Rats chronically received either the probiotic mixture (1.10(9) CFU/day) or the vehicle. Anxiety- and depressive-like behaviors were evaluated in several tests. Brain monoamine levels and gut RNA expression of tight junction proteins (Tjp) and inflammatory markers were quantified. The gut microbiota was analyzed in feces by 16S rRNA gene sequencing. Untargeted metabolite analysis reflecting primary metabolism was performed in the cecal content and in serum. Fischer rats treated with the probiotic mixture manifested a decrease in anxiety-like behaviors, in the immobility time in the forced swimming test, as well as in levels of dopamine and its major metabolites, and those of serotonin metabolites in the hippocampus and striatum. In maternally deprived Long Evans rats treated with the probiotic mixture, the number of entries into the central area in the open-field test was increased, reflecting an anxiolytic effect. The probiotic mixture increased Tjp1 and decreased Ifn gamma mRNA levels in the ileum of maternally deprived rats. In both models, probiotic supplementation changed the proportions of several Operational Taxonomic Units (OTU) in the gut microbiota, and the levels of certain cecal and serum metabolites were correlated with behavioral changes. Chronic administration of the tested probiotic mixture can therefore beneficially affect anxiety- and depressive-like behaviors in rats, possibly owing to changes in the levels of certain metabolites, such as 21-deoxycortisol, and changes in brain monoamines.
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Details
- Title
- A Probiotic Mixture Induces Anxiolytic- and Antidepressive-Like Effects in Fischer and Maternally Deprived Long Evans Rats
- Creators
- Valérie Daugé - Microbiologie de l’alimentation au service de la santéCatherine Philippe - Microbiologie de l’alimentation au service de la santéMahendra Mariadassou - Université Paris-SaclayOlivier Rué - Université Paris-SaclayJean-Charles Martin - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition researchMarie-Noelle Rossignol - Université Paris-SaclayNathalie Dourmap - Normandie UniversitéLjubica Svilar - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition researchFranck Tourniaire - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition researchMagali Monnoye - Microbiologie de l’alimentation au service de la santéDeborah Jardet - Université Paris-SaclayMarie Bangratz - S Group Holding (Czechia)Sophie Holowacz - S Group Holding (Czechia)Sylvie Rabot - Microbiologie de l’alimentation au service de la santéLaurent Naudon - Centre National pour la Recherche Scientifique et Technique (CNRST)Jessica R Barson - College of Medicine (2002-)
- Publication Details
- Frontiers in behavioral neuroscience, v 14, pp 581296-581296
- Publisher
- Frontiers
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Drexel University
- Web of Science ID
- WOS:000594856300001
- Scopus ID
- 2-s2.0-85097231936
- Other Identifier
- 991020099185304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences