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Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
A Radio-telemetric System to Monitor Cardiovascular Function in Rats with Spinal Cord Transection and Embryonic Neural Stem Cell Grafts
Journal of Visualized Experiments, (92), pp e51914-e51914
2014
PMID: 25350486
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
High thoracic or cervical spinal cord injury (SCI) can lead to cardiovascular dysfunction. To monitor cardiovascular parameters, we implanted a catheter connected to a radio transmitter into the femoral artery of rats that underwent a T4 spinal cord transection with or without grafting of embryonic brainstem-derived neural stem cells expressing green fluorescent protein. Compared to other methods such as cannula insertion or tail-cuff, telemetry is advantageous to continuously monitor blood pressure and heart rate in freely moving animals. It is also capable of long term multiple data acquisitions. In spinal cord injured rats, basal cardiovascular data under unrestrained condition and autonomic dysreflexia in response to colorectal distension were successfully recorded. In addition, cardiovascular parameters before and after SCI can be compared in the same rat if a transmitter is implanted before a spinal cord transection. One limitation of the described telemetry procedure is that implantation in the femoral artery may influence the blood supply to the ipsilateral hindlimb.
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Details
- Title
- A Radio-telemetric System to Monitor Cardiovascular Function in Rats with Spinal Cord Transection and Embryonic Neural Stem Cell Grafts
- Creators
- Shaoping Hou - Spinal Cord Research Center, Department of Neurobiology & Anatomy, Drexel University College of Medicine;Armin Blesch - Spinal Cord Injury Center, Heidelberg University HospitalPaul Lu - University of California, San Diego
- Publication Details
- Journal of Visualized Experiments, (92), pp e51914-e51914
- Publisher
- MyJove Corporation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000349303100034
- Scopus ID
- 2-s2.0-84908350831
- Other Identifier
- 991019167778704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences