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Journal article
A Randomized Trial Comparing Part-time Patching with Observation for Intermittent Exotropia in Children 12 to 35 Months of Age
Ophthalmology (Rochester, Minn.), v 122(8), pp 1718-1725
01 Aug 2015
PMID: 26072346
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To determine the effectiveness of part-time patching for treating intermittent exotropia (IXT) in young children.
Multicenter, randomized clinical trial.
Two hundred one children 12 to 35 months of age with untreated IXT meeting the following criteria: (1) IXT at distance OR constant exotropia at distance and either IXT or exophoria at near, and (2) 15-prism diopter (Δ) or more exodeviation at distance or near by prism and alternate cover test (PACT) but at least 10 Δ exodeviation at distance by PACT.
Participants were assigned randomly to either observation (no treatment for 6 months) or patching prescribed for 3 hours daily for 5 months, followed by 1 month of no patching.
The primary outcome was deterioration, defined as constant exotropia measuring at least 10 Δ at distance and near or receipt of nonprotocol treatment for IXT.
Of the 177 participants (88%) completing the 6-month primary outcome examination, deterioration occurred in 4.6% (4 of 87) of the participants in the observation group and in 2.2% (2 of 90) of the participants in the patching group (difference, 2.4%; P = 0.27; 95% confidence interval, -3.8% to +9.4%). Motor deterioration occurred in 2.3% (2 of 87) of the observation group and in 2.2% (2 of 90) of the patching group (difference, 0.08%; P = 0.55; 95% confidence interval, -5.8% to +6.1%). For the observation and patching groups, respectively, 6-month mean PACT measurements were 27.9 Δ versus 24.9 Δ at distance (P = 0.02) and 19.3 Δ versus 17.0 Δ at near (P = 0.10); 6-month mean exotropia control scores were 2.8 versus 2.3 points at distance (P = 0.02) and 1.4 versus 1.1 points at near (P = 0.26).
Among children 12 to 35 months of age with previously untreated IXT, deterioration over 6 months was uncommon, with or without patching treatment. There was insufficient evidence to recommend part-time patching for the treatment of IXT in children in this age group.
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Details
- Title
- A Randomized Trial Comparing Part-time Patching with Observation for Intermittent Exotropia in Children 12 to 35 Months of Age
- Creators
- Pediatric Eye Disease Investigator Group (Collaboration)Brian G Mohney - University of Alabama at BirminghamSusan A Cotter - Marshall B. Ketchum UniversityDanielle L Chandler - Jaeb Center for Health ResearchJonathan M Holmes - Mayo ClinicAngela M Chen - Marshall B. Ketchum UniversityMichele Melia - Jaeb Center for Health ResearchSean P Donahue - Vanderbilt Eye Center, Nashville, TennesseeDavid K Wallace - Duke UniversityRaymond T Kraker - Jaeb Center for Health ResearchMelanie L Christian - Concord ConsortiumDonny W Suh - Wolfe Eye ClinicMitchell Scheiman - Drexel University, Pennsylvania College of Optometry (PCO)
- Publication Details
- Ophthalmology (Rochester, Minn.), v 122(8), pp 1718-1725
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- U10 EY011751 / NEI NIH HHS EY011751 / NEI NIH HHS EY018810 / NEI NIH HHS UG1 EY011751 / NEI NIH HHS U10 EY018810 / NEI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000358322900035
- Scopus ID
- 2-s2.0-84937739467
- Other Identifier
- 991021900514104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology