Journal article
A Randomized Trial of 1-and 3-Month Depot Leuprolide Doses in the Treatment of Central Precocious Puberty
The Journal of pediatrics, v 159(6), pp 982-U148
01 Dec 2011
PMID: 21798557
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective To compare 1-month and 3-month depot formulations of leuprolide acetate (DL), a gonadotropin-releasing hormone analog, in the treatment of central precocious puberty (CPP).
Study design Subjects with CPP naive to therapy were randomized to 7.5 mg of 1-month DL, 11.25 mg of 3-month DL, or 22.5 mg of 3-month DL. Stimulated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and estradiol levels, growth velocity, and bone age progression were examined in a 2-year period.
Results Forty-nine female and 5 male subjects with CPP were randomized. Mean stimulated LH and FSH levels during treatment were higher in the low-dose 11.25-mg 3-month DL group, and more LH levels >4 IU/L were observed, in comparison with the other two dose groups. Mean LH and FSH levels in the 22.5-mg 3-month group were not different from the monthly DL. No differences in estradiol levels, growth velocity, or bone age progression were observed in dosing groups.
Conclusions All DL doses resulted in prompt and effective suppression of puberty, but higher LH and FSH levels were seen with the 11.25-mg 3-month DL dose. Multi-monthly DL is effective in treating CPP, but higher dosing may be required in some circumstances. (J Pediatr 2011;159:982-7).
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Details
- Title
- A Randomized Trial of 1-and 3-Month Depot Leuprolide Doses in the Treatment of Central Precocious Puberty
- Creators
- Kimberly Fuld - Drexel UniversityCarolyn Chi - Baylor College of MedicineE. Kirk Neely - Stanford University
- Publication Details
- The Journal of pediatrics, v 159(6), pp 982-U148
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- Abbott; Abbott Laboratories Endo Pharmaceuticals
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000296849400021
- Scopus ID
- 2-s2.0-80755146101
- Other Identifier
- 991019168216304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics