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Journal article
A Randomized Trial of Increasing Patching for Amblyopia
Ophthalmology (Rochester, Minn.), v 120(11), pp 2270-2277
01 Nov 2013
PMID: 23755872
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: After treatment with refractive correction and patching, some patients have residual amblyopia resulting from strabismus or anisometropia. We conducted a clinical trial to evaluate the effectiveness of increasing prescribed daily patching from 2 to 6 hours in children with stable residual amblyopia.
Design: Prospective, randomized, multicenter clinical trial.
Participants: A total of 169 children aged 3 to < 8 years (mean, 5.9 years) with stable residual amblyopia (20/32-20/160) after 2 hours of daily patching for at least 12 weeks. Intervention: Random assignment to continue 2 hours of daily patching or increase patching time to an average of 6 hours/day.
Main Outcome Measures: Best-corrected visual acuity (VA) in the amblyopic eye after 10 weeks.
Results: Baseline VA was 0.44 logarithm of the minimum angle of resolution (logMAR) (20/50(-2)). Ten weeks after randomization, amblyopic eye VA had improved an average of 1.2 lines in the 6-hour group and 0.5 line in the 2-hour group (difference in mean VA adjusted for acuity at randomization 0.6 line; 95% confidence interval, 0.3-1.0; P=0.002). Improvement of 2 or more lines occurred in 40% of participants patched for 6 hours versus 18% of those who continued to patch for 2 hours (P-0.003).
Conclusions: When amblyopic eye VA stops improving with 2 hours of daily patching, increasing the daily patching dosage to 6 hours results in more improvement in VA after 10 weeks compared with continuing 2 hours daily. (C) 2013 by the American Academy of Ophthalmology.
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Details
- Title
- A Randomized Trial of Increasing Patching for Amblyopia
- Creators
- David K. Wallace - Duke UniversityElizabeth L. Lazar - Jaeb Center for Health ResearchJonathan M. Holmes - Mayo ClinicMichael X. Repka - Johns Hopkins UniversitySusan A. Cotter - Marshall B. Ketchum UniversityAngela M. Chen - Marshall B. Ketchum UniversityRaymond T. Kraker - Jaeb Center for Health ResearchRoy W. Beck - Jaeb Center for Health ResearchMichael P. Clarke - Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, EnglandIngryd J. Lorenzana - Adv Vis Ctr, Schaumburg, IL USADavid B. Petersen - Eye Care AssociatesJoan T. Roberts - North Carolina Eye Ear & Throat, Durham, NC USADonny W. Suh - Wolfe Eye ClinicPediat Eye Dis Investigator GrpMitchell Scheiman - Pennsylvania College of Optometry (PCO)
- Publication Details
- Ophthalmology (Rochester, Minn.), v 120(11), pp 2270-2277
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- U10EY011751 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) National Eye Institute of National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) EY011751; EY018810 / Department of Health and Human Services
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000326681700024
- Scopus ID
- 2-s2.0-84887194101
- Other Identifier
- 991021900191004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Ophthalmology