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A Randomized Trial of Near Versus Distance Activities While Patching for Amblyopia in Children Aged 3 to Less Than 7 Years
Journal article   Open access   Peer reviewed

A Randomized Trial of Near Versus Distance Activities While Patching for Amblyopia in Children Aged 3 to Less Than 7 Years

Jonathan M. Holmes, Don W. Lyon, O. D. Samara, Pediat Eye Dis Investigator Grp and Mitchell Scheiman
Ophthalmology (Rochester, Minn.), v 115(11), pp 2071-2078
01 Nov 2008
DOI: https://doi.org/10.1016/j.ophtha.2008.06.031
PMID: 18789533
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc2615691View
Accepted (AM)Open Access (License Unspecified),  Open
url
https://doi.org/10.1016/j.ophtha.2008.06.031View
Published, Version of Record (VoR) Open

Abstract

Life Sciences & Biomedicine Ophthalmology Science & Technology
Purpose: To determine whether performing near activities while patching for amblyopia enhances improvement in visual acuity. Design: Randomized clinical trial. Participants: A total of 425 children, aged 3 to < 7 years, with amblyopia (20/40-20/400) that was caused by anisometropia, strabismus, or both, and that persisted after treatment with spectacles. Methods: Children were randomized to 2 hours of patching per day with near activities or 2 hours of patching per day with distance activities. Instruction sheets describing common near and distance activities were given to the parents. Study visits were scheduled at 2, 5, 8, and 17 weeks. In weeks without a visit, weekly telephone calls were made to the parent to monitor and encourage compliance during the first 8 weeks. Main Outcome Measure: Masked assessment of visual acuity by isolated crowded HOTV optotypes at 8 weeks. Results: At 8 weeks, improvement in amblyopic eye visual acuity averaged 2.6 lines in the distance activities group and 2.5 lines in the near activities group (mean difference in acuity between groups, adjusted for baseline acuity, 0.0 lines 95% confidence interval, -0.3 to 0.3). The 2 groups also appeared statistically similar at the 2-, 5-, and 17-week visits. At the 17-week examination, children with severe amblyopia improved a mean of 3.6 lines with 2 hours of daily patching. Conclusions: Performing common near activities does not improve visual acuity outcome when treating anisometropic, strabismic, or combined amblyopia with 2 hours of daily patching. Children with severe amblyopia may respond to 2 hours of daily patching.

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Ophthalmology
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