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A Rare Case of Adrenal Carcinoma With Isolated Hypercortisolism Mimicking Hyperaldosteronism
Journal article   Open access   Peer reviewed

A Rare Case of Adrenal Carcinoma With Isolated Hypercortisolism Mimicking Hyperaldosteronism

Sai Rakshith Gaddameedi, Axle D. Untalan, Malay Rathod, Phani Bhavana Cherukuri, Vandana Bandari, Manjula Ashok and Doantrang Du
Curēus (Palo Alto, CA), v 16(6), 61481
01 Jun 2024
DOI: https://doi.org/10.7759/cureus.61481
PMID: 38827415
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.7759/cureus.61481View
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Abstract

General & Internal Medicine Life Sciences & Biomedicine Medicine, General & Internal Science & Technology
We report a case of a 22-year-old female with pedal edema, hypokalemia, and hypertension. On suspicion of hyperaldosteronism, further workup was pursued, which only revealed a low serum adrenocorticotropic hormone (ACTH) and an inappropriately normal cortisol level after a 1 -mg dexamethasone suppression test, suggestive of primary hypercortisolism. CT of the chest, abdomen, and pelvis revealed a left adrenal mass. Based on the clinical findings and biochemical abnormalities, we were expecting this tumor to be aldosterone-secreting, but both serum aldosterone and renin levels were normal in our patient. Eventual surgical resection confirmed initial suspicions of malignancy, as it was found to be adrenal cortical carcinoma. This case highlights the unusual presentation of this rare but aggressive endocrinologic neoplasm and the importance of its prompt diagnosis and treatment.

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Web of Science research areas
Endocrinology & Metabolism
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