Journal article
A Retrospective Review of 61 Patients With Antiphospholipid Syndrome: Analysis of Factors Influencing Recurrent Thrombosis
Archives of internal medicine (1960), v 157(18), pp 2101-2108
13 Oct 1997
PMID: 9382667
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Abstract
BACKGROUND: Antiphospholipid syndrome (APS) is a disorder of recurrent venous or arterial thrombosis, pregnancy losses, and thrombocytopenia. Recurrent thrombosis has particularly adverse effects on patient prognosis. The factors that influence recurrence and management techniques that prevent these events remain controversial. To add further insight regarding predisposing factors and the prevention of thrombotic recurrence, 61 wellcharacterized patients with APS were followed up for a median time of 77 months. METHODS: A retrospective cohort study was conducted in which the following factors were examined to determine their influence on thrombotic recurrence: primary vs secondary syndrome; the presence of hypertension, hyperlipidemia, diabetes, or smoking; patient age, sex, and race; pregnancy and oral contraceptives use; and treatment with warfarin sodium, warfarin plus aspirin, aspirin alone, prednisone, or no treatment. RESULTS: There was no difference between patients with primary and secondary APS with respect to recurrent arterial (55% vs 38%, respectively) or recurrent venous (47% vs 50%, respectively) thrombotic events. In all patients with APS, white race (P=.02) was associated with recurrent arterial events. Venous thrombosis occurred during pregnancy or in the postpartum period in 16 (30%) of 53 women and in 8 women taking oral contraceptives. Recurrent arterial and venous thromboses were significantly decreased with prophylactic warfarin use when compared with prednisone use or no treatment. Recurrences were infrequent in patients with prothrombin ratios of 1.5 to 2.0. CONCLUSIONS: Treatment with warfarin was most effective in preventing recurrent arterial and venous thrombosis. Pregnancy and the use of oral contraceptives or prednisone may also influence recurrence.Arch Intern Med. 1997;157:2101-2108
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Details
- Title
- A Retrospective Review of 61 Patients With Antiphospholipid Syndrome: Analysis of Factors Influencing Recurrent Thrombosis
- Creators
- Sanja Krnic-BarrieCarolyn Riester O'ConnorStephen W LooneySilvia S PierangeliE. Nigel Harris
- Publication Details
- Archives of internal medicine (1960), v 157(18), pp 2101-2108
- Publisher
- American Medical Association; CHICAGO
- Number of pages
- 8
- Grant note
- FIC NIH HHS: 1 FO5 TWO 4936-01
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Rheumatology
- Web of Science ID
- WOS:A1997YA44200012
- Scopus ID
- 2-s2.0-0030924102
- Other Identifier
- 991021955781804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Rheumatology